Glucomet 750 XR 10pcs Tablet

✔️ Uses of Glucomet 750 XR 10pcs Tablet

Type 2 Diabetes Mellitus.

✔️ How does Glucomet 750 XR 10pcs Tablet work?

• Belongs to the Biguanide class.
• Lowers glucose production in the liver.
• Delays sugar absorption from the intestines.
• Increases body sensitivity to insulin.

✔️ Side Effects of Glucomet 750 XR 10pcs Tablet

• Common: Gastrointestinal issues (nausea, vomiting, diarrhea, abdominal pain, loss of appetite).
• Very rare: Hemolytic anemia, lactic acidosis, taste disturbances, encephalopathy, skin reactions.
• Peripheral neuropathy is reported in cases of vitamin B12 deficiency.

✔️ Quick Suggestions:

• Metformin is prescribed to control blood sugar levels and reduce the risk of diabetic complications, such as heart attacks.
• It is associated with lesser chances of weight gain compared to other diabetes medicines.
• While the risk of low blood sugar (hypoglycemia) is lower, it may still occur, especially when taken with other antidiabetic medicines, alcohol, or in case of delaying/skipping meals.
• Carry a sugar source with you for immediate relief in case of hypoglycemia.
• Notify your doctor immediately if you experience deep or rapid breathing, persistent nausea, vomiting, or stomach pain. These could be signs of lactic acidosis, a rare but serious condition.
• Prolonged use of Metformin may lead to vitamin B12 deficiency.
• Symptoms of deficiency include fatigue, pale skin, shortness of breath, or headache.
• Inform your doctor if you experience these symptoms, as you may require supplements.
• Your doctor will monitor your blood sugar levels and kidney functions regularly while you are on this medication.

✔️ Indicatio of Glucomet 750 XR 10pcs Tablet

• Treatment of type 2 diabetes mellitus in overweight patients when diet and exercise alone are insufficient.
• Can be used alone or with other oral antidiabetic drugs or insulin in adults.
• Suitable for children and adolescents (as young as ten years old).

✔️ Pharmacology

• Antihyperglycemic medication of the biguanide class.
• Reduces baseline and postprandial plasma glucose levels.
• Enhances insulin sensitivity, increasing peripheral glucose uptake and utilization.
• Does not cause hypoglycemia.
• Lowers hepatic glucose production and intestinal glucose absorption.

✔️ Dosage & Administration:

• Immediate-release tablet: Starting dose of 500 mg or 850 mg (adults) twice a day or once a day with meals. Can be increased gradually.
• Extended-release tablet: Starting dose of 500 mg (adults) once daily with the evening meal. Incremental increases up to a maximum of 2000 mg once daily or 1000 mg twice daily.
• Not studied in children. Avoid in renal impairment (eGFR < 30 mL/min/1.73 m2).

✔️ Interaction

• The risk of lactic acidosis increased with carbonic anhydrase inhibitors.
• Drugs inhibiting Metformin clearance (e.g., Ranolazine, dolutegravir, Cimetidine) may cause Metformin buildup.
• Alcohol can amplify Metformin's effect on lactate metabolism.

✔️ Contraindications

• Hypersensitivity to the active ingredient or any excipient.
• Acute metabolic acidosis (lactic acidosis, diabetic ketoacidosis).
• Renal failure (GFR < 30 mL/min), dehydration, severe infection, shock.
• Conditions causing tissue hypoxia (e.g., cardiac or respiratory failure, recent myocardial infarction).
• Hepatic insufficiency, acute alcohol intoxication, alcoholism.

✔️ Pregnancy & Lactation

• Pregnancy: Not recommended; insulin preferred for glycemic control to reduce fetal malformation risk.
• Breastfeeding: Secreted in breast milk; limited data available, not recommended during treatment.

✔️ Precautions & Warnings

• Metformin is substantially excreted by the kidney; risk of accumulation and lactic acidosis in renal impairment.
• May lower vitamin B12 levels.
• Increased risk of hypoglycemia when used with insulin or insulin secretagogues.

✔️ Storage Conditions

Keep below 30°C, protected from light and moisture. Keep out of reach of children.