Tenivasc 20/5 Tablet

✔️ Therapeutic Use

Management of hypertension to reduce cardiovascular risk

✔️ Dosage & Administration

Initial dose: 5 mg/20 mg once daily

Dose adjustment: May be increased after 1–2 weeks based on response

Maximum dose: 10 mg/40 mg per day

Elderly: Consider a lower starting dose

Hepatic impairment: Use with caution in mild to moderate impairment

Can be taken with or without food

1. Avoid use in severe renal impairment (CrCl < 20 mL/min)
2. Renal function may worsen when combined with NSAIDs

✔️ Side Effects

Common (>10%)

Peripheral edema

Other Possible Effects

Palpitations

Orthostatic hypotension

Increased urinary frequency or nocturia

Skin reactions (rash, pruritus)

Rare but Serious

Acute renal failure

✔️ Drug Interaction

Enhanced hypotensive effects with other antihypertensives

Increased risk of hyperkalemia with potassium-sparing diuretics, potassium supplements, ACE inhibitors, ciclosporin, or eplerenone

NSAIDs may reduce antihypertensive efficacy and impair renal function

May increase lithium levels and toxicity

Caution when used with clonidine, catecholamine-depleting drugs, or prostaglandin synthesis inhibitors

✔️ Pregnancy category:

Category C (1st trimester)

Category D (2nd & 3rd trimesters)

Not recommended during breastfeeding due to the potential risk to the infant

✔️ Precautions & Warnings

Drugs affecting the renin-angiotensin system may cause fetal injury or death during the 2nd and 3rd trimesters

Discontinue immediately if pregnancy is detected

Risk of symptomatic hypotension in volume- or salt-depleted patients

Monitor renal function and serum potassium, especially in renal impairment

Avoid use in severe renal or hepatic impairment

Use cautiously in patients with aortic or mitral stenosis, hypertrophic cardiomyopathy, or renal artery stenosis

Patients with primary aldosteronism may respond poorly

✔️ Storage:

Do not store above 30°C. Keep away from light and out of the reach of children