Joinflex M 20mg+750mg+50mg+0.75mg Tablet

Undenatured Type II collagen: Undenatured Type II collagen is a nutritional supplement derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured Type II collagen has a unique mechanism of action. Undenatured Type II collagen molecules contain active binding sites called epitopes, which trigger the process of oral tolerization. Through the oral tolerization process, active epitopes of Undenatured Type II collagen interact with Peyer’s patches (lymphoid tissue) of the small intestine, and this transforms T-cells into T regulatory cells. T regulatory cells then migrate to the joint area and secrete anti-inflammatory mediators (cytokines), including transforming growth factor-beta (TGF-beta) and interleukin 10 (IL-10). Thus, it reduces joint inflammation and promotes cartilage repair. According to ORSI (Osteoarthritis Research Society International), oral administration of Undenatured Type II collagen diminished deterioration of articular cartilage in osteoarthritis (OA).

Glucosamine sulfate: Glucosamine sulfate is a natural supplement. It is a sugar protein that helps to build cartilage. Glucosamine, a normal constituent of glycosaminoglycans in cartilage matrix and synovial fluid, could have various pharmacological actions in articular cartilage and joint tissues. In a randomized, placebo-controlled clinical trial, long-term administration of Glucosamine sulphate can prevent joint structure changes in patients with osteoarthritis of the knee, with a significant improvement in symptoms.

Boswellia serrata: This plant extract promotes joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Extract of Boswellia serrata has been clinically studied for osteoarthritis, joint function & joint pain. Boswellia may also help reduce cartilage damage in arthritis. In a placebo-controlled clinical study, Boswellia extract improves signs of joint discomfort in just 8 weeks. Boswellia serrata is a promising alternative to NSAIDs.

Boron (calcium fructoborate): It is a patented complex of calcium, fructose & boron found naturally in fresh and dried fruits, vegetables and herbs. Calcium fructoborate significantly reduces C-reactive protein in humans. This unique plant-mineral complex contributes to bone health by controlling the inflammation associated with loss of bone mineral density.

There have been no reports of significant drug Interactions of Undenatured Type II collagen, Boswellia serrata, Glucosamine sulfate, Calcium fructoborate. But in the case of Glucosamine sulfate & Boswellia serrata, there is a chance of drug interaction with blood thinner medications (e,g warfarin, heparin).