Arodin 5% Ointment 25g Tube

Arodin contains Povidone-Iodine, a broad-spectrum antiseptic used in different formulations for the prevention and treatment of infections of the skin, wounds, mucous membranes, and other affected areas.

Indications

Ointment 5%

Therapeutic use:
As an adjunct to systemic treatment for:

• Primary or secondary bacterial skin infections
• Infected surgical wounds or incisions
• Infected pressure sores and stasis ulcers
• Pyoderma
• Secondarily infected skin diseases
• Infected traumatic wounds or lesions

Prophylactic use:

• Prevention of microbial contamination of burns, surgical incisions, and other skin lesions
• Antiseptic preparation of skin in selected medical procedures
• Prevention of infection in abrasions, minor cuts, and superficial wounds
• Support of normal wound healing by reducing microbial contamination

Solution

Povidone-Iodine Solution is used for:

• Prevention and treatment of superficial skin infections
• Antiseptic cleansing of skin and mucous membranes
• Treatment of seborrhoeic conditions where antiseptic cleansing is indicated
• Preoperative and postoperative cleansing of surgical areas
• Preparation of the operative site, including selected gynecological procedures
• Disinfection of wounds, burns, lacerations, and abrasions
• Prevention of infection during appropriate household, hospital, and clinical procedures
• Postoperative application to surgical incisions when indicated
• Management of selected bacterial and fungal skin infections, pressure sores, and stasis ulcers
• Antiseptic preparation of the mouth and throat before certain procedures

Gargle & Mouthwash

It is used for:

• Treatment of acute infections of the mouth and throat
• Maintaining oral hygiene before, during, and after dental or oral surgery

Surgical Scrub

Povidone-Iodine Surgical Scrub is a medicated antiseptic cleanser that produces a rich lather. It is used for:

• Preoperative and postoperative hand and forearm cleansing by surgeons and operating-room personnel
• Preoperative antiseptic preparation of patients' skin
• General surgical or clinical cleansing when an antiseptic scrub is required

Powder

Povidone-Iodine Powder may be applied topically for the prevention and treatment of infection associated with:

• Superficial wounds
• Minor cuts
• Burns
• Abrasions
• Lacerations
• Other superficial skin lesions

Ophthalmic Solution

Povidone-Iodine ophthalmic preparations are used as topical ocular antiseptics, particularly for reducing microbial contamination of the ocular surface before certain ophthalmic procedures.

Note: The supplied source describes the ophthalmic preparation as a treatment for dry eye and as a tear substitute. This indication is not consistent with povidone-iodine's usual pharmacological role, so the specific product formulation and registered indication should be verified before publishing that claim.

Pharmacology

Povidone-Iodine is a complex of iodine and povidone, a water-soluble polymer. The complex gradually releases free iodine, which provides broad-spectrum antimicrobial activity while generally causing less irritation than elemental iodine.

Free iodine rapidly inactivates microorganisms by disrupting cellular proteins and other essential structures. Povidone-Iodine is active against a wide range of Gram-positive and Gram-negative bacteria, fungi, yeasts, viruses, protozoa, and spores.

Its antimicrobial activity can remain effective in the presence of substances such as blood, serum, pus, mucosal secretions, and water.

Dosage & Administration

Cream or Ointment

For treatment of infection:
Apply a thin layer to the affected area once or twice daily or during dressing changes, generally for up to 14 days unless otherwise directed by a physician.

For prevention of infection:
Apply once or twice weekly, or as advised by a healthcare professional. Clean and dry the affected area before application. A dressing or bandage may be applied when appropriate.

Solution

Apply the solution at full strength as required by the indication. It may be used as a paint, spray, or wet soak and may be covered with a dressing when appropriate.

Gargle & Mouthwash

Adults and children over 6 years:
Use undiluted or dilute with an equal volume of warm water. Gargle or rinse with up to 10 mL for approximately 30 seconds, without swallowing.

It may be used up to 4 times daily for a maximum of 14 consecutive days, unless otherwise directed by a registered physician or dental surgeon.

Surgical Scrub

For operating-room personnel:
Wet the hands and forearms, apply approximately 5 mL of Povidone-Iodine Surgical Scrub, and thoroughly scrub all areas for approximately 5 minutes, paying particular attention to the fingernails. Add water to produce a rich lather and rinse thoroughly. Repeat the procedure with another approximately 5 mL when required by the surgical protocol.

For preoperative preparation of patients:
Wet the area with water after shaving when necessary. Apply sufficient surgical scrub to cover the area, develop a lather, and scrub thoroughly for approximately 5 minutes. Remove with sterile gauze moistened with water.

Powder

Apply a light layer of powder over the affected area. Once dry, it forms an antiseptic protective layer. Use only as directed by a healthcare professional.

Ophthalmic Solution

The dose depends on the specific ophthalmic formulation and clinical indication. If the registered product is indicated for ocular antisepsis, it should be administered strictly according to the ophthalmologist's or manufacturer's instructions.

Drug Interactions

Povidone-Iodine may interact chemically with:

• Strong alkalis
• Sodium thiosulfate
• Sodium metabisulfite
• Thiomersal

Regular or prolonged use in patients receiving lithium may increase the risk of thyroid dysfunction because of iodine exposure.

Contraindications

Arodin should not be used in patients with known hypersensitivity to povidone-iodine or any component of the formulation.

Regular or prolonged use should generally be avoided or carefully supervised in patients with:

• Thyroid disorders, particularly nodular or endemic goitre and Hashimoto's thyroiditis
• Concurrent lithium therapy
• Significant renal impairment, particularly when extensive or repeated application is required

Povidone-Iodine powder should not be applied to deep body cavities or used in children under 2 years of age unless specifically advised by a physician.

Side Effects

Possible adverse effects include:

• Skin irritation
• Irritation of mucous membranes
• Redness or discomfort
• Hypersensitivity reactions

Extensive application, particularly over large areas of damaged skin or severe burns, may increase systemic iodine absorption and potentially cause:

• Metabolic disturbances
• Hypernatraemia
• Impaired kidney function
• Changes in thyroid function

Povidone-Iodine may also interfere with certain thyroid function tests.

Pregnancy & Lactation

Pregnancy:
Extensive or repeated use of povidone-iodine during pregnancy is generally not recommended because absorbed iodine may affect fetal thyroid function. Use only when specifically considered necessary by a healthcare professional.

Breastfeeding:
Limited amounts may be absorbed depending on the formulation and extent of application. Repeated or extensive use should be avoided unless recommended by a physician.

Gargle & Mouthwash/Surgical Scrub:
Regular or prolonged use during pregnancy and breastfeeding should be avoided unless specifically advised by a healthcare professional.

Ophthalmic preparation:
Adequate safety data in human pregnancy and breastfeeding may be limited. Use only when clearly indicated and under medical supervision.

Precautions & Warnings

Ointment/Cream:

• Consult a physician before treating deep puncture wounds or serious burns.
• Discontinue use and seek medical advice if redness, swelling, irritation, pain, or infection persists or worsens.

Solution:

• Avoid prolonged contact with wet povidone-iodine solution, particularly during preoperative preparation, as this may cause skin irritation.
• Prevent pooling of solution beneath the patient during surgical preparation.
• Deep wounds and serious burns require medical assessment.

Gargle & Mouthwash:

• Do not swallow the preparation.
• Avoid prolonged or continuous use because significant iodine absorption may occur.
• Do not use for more than 14 days unless advised by a healthcare professional.
• Not recommended for children under 6 years.
• Patients taking lithium should consult their physician before use.

Surgical Scrub:

• Use caution when repeatedly applying to broken skin, particularly in patients with renal impairment.
• Avoid regular use in patients receiving lithium unless medically supervised.
• Povidone-Iodine may permanently discolor certain white-gold jewelry; remove such jewelry before use.

Powder:

• Use cautiously in patients with known iodine sensitivity.
• Excess powder can be removed with warm water.
• For external use only; do not ingest.
• Apply directly from the container to minimize contamination.

Ophthalmic Solution:

• Use only according to the specific ophthalmic product instructions.
• Avoid touching the dropper tip to the eye or other surfaces.
• Contact lenses should generally be removed before administration and should not be reinserted until the appropriate interval has passed.
• Temporary blurred vision may occur after ocular administration; avoid driving or operating machinery until vision becomes clear.

Therapeutic Class

Iodine Compounds – Antiseptic Preparations

Storage Conditions

Store below 25°C in a cool, dry place protected from light. Do not freeze. Keep out of reach of children.

For ophthalmic preparations:

• Do not touch the dropper tip to the eye or any other surface.
• Keep the container tightly closed after use.
• Do not use the ophthalmic preparation after 1 month from first opening, unless the product label specifies a different period.