Cozopt 2%+0.5% Eye Drops 5ml

✔️ Directions for Use:

1. Wash your hands before applying the eye drops.
2. Tilt your head back and gently pull down the lower eyelid.
3. Hold the dropper close to the eye without touching the eye, eyelid, eyelashes, or any other surface.
4. Instill one drop into the conjunctival sac.
5. Close the eye gently after application.
6. Avoid excessive blinking immediately after instillation.
7. Apply gentle pressure to the inner corner of the eye near the nose for approximately 1 minute to reduce systemic absorption.
8. If using another ophthalmic medicine, maintain an appropriate interval between the two medicines as directed by your doctor.

✔️ Dosage & Administration

Adults

Instill 1 drop into the conjunctival sac of the affected eye(s) twice daily, or use exactly as prescribed by the ophthalmologist.

Pediatric Patients

The safety and effectiveness of Cozopt in children below 2 years of age have not been established.

Elderly Patients

No clinically significant overall differences in safety or effectiveness have been observed between elderly patients and other adult patients.

✔️ Cozopt is contraindicated in patients with:

• Known hypersensitivity to dorzolamide, timolol, or any component of the formulation

Because timolol is a beta-blocker, patients with certain cardiovascular or respiratory conditions may require additional evaluation before treatment.

✔️ Drug Interaction

Cozopt may produce additive cardiovascular or systemic effects when used with certain medicines, including:

• Oral calcium-channel blockers
• Catecholamine-depleting medicines
• Other beta-blockers
• Antiarrhythmic medicines such as amiodarone
• Digitalis glycosides
• Parasympathomimetic medicines
• Narcotic medicines
• Monoamine oxidase inhibitors (MAOIs)
• Oral carbonic anhydrase inhibitors

Concomitant use with systemic carbonic anhydrase inhibitors or other beta-blockers may increase systemic adverse effects.

CYP2D6 inhibitors, such as quinidine and some SSRIs, may increase systemic beta-blockade associated with timolol.

Patients should inform their doctor about all medicines, vitamins, and supplements they are taking before starting treatment.

✔️ Pregnancy & Lactation

Pregnancy

There are no adequate and well-controlled studies of Cozopt in pregnant women. The medicine should be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, as determined by a healthcare professional.

Lactation

Caution should be exercised when Cozopt is administered to breastfeeding mothers. The decision to use the medicine during lactation should be made by a healthcare professional after considering the potential benefits and risks.

✔️ Side Effects

• Mild burning or stinging
• Ocular hyperemia (eye redness)
• Blurred vision

✔️ Safety Information:

• For ophthalmic use only.
• Do not swallow the eye drops.
• Remove contact lenses before instilling Cozopt.
• Wait at least 15 minutes after instillation before reinserting contact lenses.
• Avoid touching the dropper tip to the eye or any other surface to prevent contamination.
• If blurred vision occurs after administration, avoid driving or operating machinery until vision becomes clear.
• Do not discontinue treatment without consulting your ophthalmologist, as uncontrolled intraocular pressure may lead to progressive eye damage.
• Inform your doctor if you are using other eye drops or systemic beta-blockers.

✔️ Storage:

• Store in a cool and dry place.
• Protect from light.
• Keep out of the reach of children.
• Do not use the preparation for longer than one month after first opening, unless the product-specific instructions state otherwise.
• Keep the container properly closed when not in use.