Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes, resulting in increased membrane permeability and leakage of essential constituents of fungal cells.
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Aristen sterile eye ointment is indicated for the treatment of fungal keratitis due to filamentous fungi and Candida species. It should be applied thinly and evenly to the conjunctival sac every 4 hours or as advised by a physician.
Clotrimazole ointment is contraindicated in individuals sensitive to its components.
Pregnancy category B. There are no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy. Clotrimazole should be used only if clearly indicated during the first trimester of pregnancy.
It is not known whether this drug is excreted in human milk; caution should be exercised when Clotrimazole is used by a nursing woman.
If irritation or sensitivity develops with the use of Aristen ointment, treatment should be discontinued.
Safety and effectiveness in children have been established for Aristen when used as indicated and in the recommended dosage.
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