Acyclovir is an antiviral agent that is highly active in vitro against Herpes simplex (HSV) types I and II and Varicella zoster viruses, but its toxicity to mammalian cells is low. Acyclovir is phosphorylated to the active compound Acyclovir triphosphate after entry into a herpes-infected cell. The first step in this process requires the presence of the viral-coded thymidine kinase. Acyclovir triphosphate acts as an inhibitor of and substrate for the herpes specified DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes.
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Acyvir is indicated for the treatment of Herpes simplex keratitis.
The dosage for all age groups is the same. A 10 mm ribbon of the ointment should be placed inside the lower conjunctival sac five times a day at approximately four-hourly intervals. Treatment should continue for at least 3 days after healing
No clinically significant interactions have been identified.
Acyclovir is contraindicated in patients known to be hypersensitive to Acyclovir or Valacyclovir
Pregnancy category B. There are no adequate and well-controlled studies of Acyclovir in pregnant women. It is not known whether topically applied Acyclovir is excreted in breast milk.
The recommended dosage, frequency of applications, and length of treatment should not be exceeded.
No adverse effects would be expected if the entire contents of the tube containing 90 mg Acyclovir were ingested orally.
Store in a cool and dry place. Keep away from light. Keep out of reach of children. Do not touch the tip of the tube since this may contaminate the product. After one month of opening, do not use the medicine in the tube.
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