Tridopa 200mg+50mg+200mg Tablet | 1 Strip

✔️ Words of Advice:

• May cause dizziness, drowsiness, or orthostatic hypotension—caution with driving or operating machinery.
• Regular monitoring of liver, kidney, blood, and cardiovascular function is recommended during long-term use.
• Monitor for psychiatric changes (hallucinations, depression).

✔️ Overdose Effects

Symptoms: Agitation, confusion, coma, bradycardia, arrhythmias, abnormal breathing, skin/mucosal discoloration, chromaturia.

Management: Supportive care, gastric lavage, repeated charcoal administration. Pyridoxine is not effective.

✔️ Dosage & Administration

The optimum daily dose must be individualized through careful levodopa titration.

One tablet = one treatment dose. Maximum daily entacapone dose: 2000 mg.

To be taken orally, with or without food. Tablets must be swallowed whole.

✔️ Patient Switching

From levodopa/carbidopa + entacapone: Switch to equivalent strength of Tridopa.

From levodopa/benserazide + entacapone: Stop benserazide at night; start Tridopa next morning with equivalent or slightly higher levodopa dose.

Patients not on entacapone: Introduce entacapone separately first in patients with high levodopa dose (>800 mg) or dyskinesia, then switch to Tridopa.

Dose adjustment: Levodopa dose may need to be reduced by 10–30% after initiation due to enhanced effect. Adjust dosing interval or strength accordingly.

✔️ Side Effects

Common: Dyskinesia, nausea, abdominal pain, diarrhea, urine discoloration

Others: Hallucinations, confusion, orthostatic hypotension, colitis, rhabdomyolysis, NMS-like symptoms, fibrosis, risk of skin cancer (melanoma)

✔️ Drug Interactions

Antihypertensives: May cause postural hypotension; dose adjustment may be required.

Dopamine antagonists (antipsychotics, antiemetics), phenytoin, papaverine: May reduce the levodopa effect.

High-protein diets: Can impair the absorption of levodopa.

✔️ Contraindications:

• Severe hepatic impairment
• Narrow-angle glaucoma
• Pheochromocytoma
• Concomitant use with non-selective MAO inhibitors (e.g. phenelzine, tranylcypromine)
• History of Neuroleptic Malignant Syndrome (NMS) or rhabdomyolysis
• Known hypersensitivity to levodopa, carbidopa, entacapone, or excipients

✔️ Pregnancy & Lactation

Pregnancy Category C: Use only if benefits outweigh risks.

Breastfeeding: Not recommended; safety unknown.

✔️ Storage

Store below 30°C, away from light and moisture.

Keep out of reach of children.