Diflu Powder for Suspension 35ml

✔️ Dosage & Administration

Adults

The following are general reference regimens. The appropriate dose and duration must be determined by a registered physician according to the infection, patient characteristics, and current prescribing guidance.

• Vaginal candidiasis: A single 150 mg oral dose may be prescribed for uncomplicated infection.
• Oropharyngeal candidiasis: Treatment may begin with 200 mg on the first day, followed by 100 mg daily for approximately 7–14 days or as clinically indicated.
• Esophageal candidiasis: Treatment may begin with 200 mg on the first day, followed by 100 mg daily. Treatment generally continues for at least 2–3 weeks and according to clinical response.
• Tinea corporis, tinea cruris, and tinea pedis: Fluconazole may be prescribed according to the type and severity of the infection.
• Kerion: Treatment depends on the underlying fungal infection and may require additional therapy.
• Pityriasis versicolor: An intermittent oral regimen may be prescribed when appropriate.
• Onychomycosis: Treatment may involve intermittent dosing over several months, with duration determined by nail growth and clinical response.
• Invasive candidiasis and cryptococcal infections: Higher initial and maintenance doses may be required under specialist supervision.
• Prevention of cryptococcal meningitis or other fungal infections: The regimen depends on the patient's underlying condition and level of immunosuppression.

Children

Fluconazole dosing is calculated according to body weight, age, infection type, and severity. Superficial and systemic fungal infections require different regimens. Children with serious infections need specialist-directed treatment.

✔️ Pregnancy & Lactation

Pregnancy: Oral fluconazole is generally avoided for vaginal candidiasis during pregnancy; topical antifungal treatment is usually preferred. For other infections, use during pregnancy requires an individual assessment of potential benefits and risks. High-dose or prolonged exposure may pose additional fetal risks.

Breastfeeding: Fluconazole passes into breast milk. Whether treatment is appropriate depends on the dose, duration, and clinical circumstances. Consult a doctor before use while breastfeeding.

✔️ Side Effects:

• Nausea
• Abdominal discomfort
• Diarrhoea
• Vomiting
• Headache
• Skin rash

✔️ Interaction

Fluconazole can alter the blood levels or effects of other medicines. Important interactions include:

• Warfarin and related anticoagulants: May increase the risk of bleeding; monitoring may be required.
• Sulfonylurea diabetes medicines: May increase the risk of hypoglycaemia.
• Phenytoin: Blood levels may rise, potentially causing toxicity.
• Rifampicin: May reduce fluconazole exposure and affect treatment response.
• Ciclosporin and tacrolimus: Levels may increase, raising the risk of toxicity.
• Hydrochlorothiazide: May increase fluconazole concentrations.
• Theophylline: Fluconazole may reduce its clearance and increase the risk of adverse effects.

✔️ Contraindications:

Fluconazole should not be used in patients with a known hypersensitivity to fluconazole or related triazole antifungal medicines. It may also be unsuitable with certain medicines that can cause serious heart rhythm disturbances.

✔️ Precautions & Warnings

• Use cautiously in patients with liver or kidney disease.
• Liver function tests may be required before or during prolonged treatment.
• Discontinue treatment and seek medical advice if a new rash develops, particularly if it is severe, blistering, or accompanied by fever.
• Patients with AIDS, cancer, or other serious underlying conditions may be at increased risk of complications.
• Review all current medicines for potential interactions before starting treatment.
• Do not use fluconazole for an undiagnosed infection or change the prescribed dose without medical advice.

✔️ Storage:

Store in a dry place, away from excessive heat and direct light. Keep out of the reach of children. Follow the product label for any specific storage requirements, particularly for oral suspension after reconstitution.