Gonagen 75IU IM/SC Injection

✔️ Side Effects: Gonagen 75IU

• Fever, chills, fatigue, and flu-like symptoms.
• Muscle and joint pain.
• Nausea, vomiting, diarrhea, abdominal cramps, and bloating.
• Pain, redness, rash, swelling, or irritation at the injection site.
• Skin rash.
• Dizziness, rapid heartbeat, or breathing difficulties.

✔️ Dosage & Administration of Gonagen 75IU

Dosage in Women

The dose is individualized according to ovarian response and should be adjusted based on ultrasound examinations and serum estradiol measurements. Treatment generally begins with 75–150 IU of FSH daily, administered intramuscularly or subcutaneously.

If the ovaries do not respond adequately, the dose may be increased gradually under specialist supervision. Once sufficient follicular development is achieved, hCG may be administered to trigger ovulation. If estradiol levels rise too rapidly, the dose may need to be reduced.

Excessive stimulation can cause multiple follicle development and increase the risk of ovarian hyperstimulation syndrome (OHSS), particularly following hCG administration.

Dosage in Men

Treatment generally begins with hCG administered twice weekly to stimulate testosterone production. Once testosterone levels reach the desired range, Gonagen may be added to stimulate sperm production. The dose and duration depend on the patient's hormonal response and should be determined by a specialist.

✔️ Precautions & Warnings

• Treatment must be closely monitored by a fertility specialist.
• Ovarian response should be assessed using ultrasound and serum estradiol measurements before and during treatment, often every one to two days as clinically indicated.
• Treatment should be stopped if unintended ovarian hyperstimulation develops.
• Women with PCOS may be at increased risk of OHSS.
• Fertility treatment may increase the risk of multiple pregnancy, miscarriage, and ectopic pregnancy.
• Severe OHSS can cause enlarged ovarian cysts, abdominal fluid accumulation, breathing difficulties, and blood clots. These complications can be life-threatening and require urgent medical attention.

✔️ Drug Interactions

Specific drug interactions have not been well established. Gonagen may be administered with hCG in men undergoing infertility treatment when prescribed by a specialist. Inform your doctor about all medicines and supplements you use.

✔️ Contraindications

In women, Gonagen should not be used in cases of:

• Pregnancy.
• Enlarged ovaries or ovarian cysts unrelated to PCOS.
• Unexplained gynecological bleeding.
• Tumours of the uterus, ovaries, or breasts.
• Hypersensitivity to menotrophins or any ingredient in the product.
• Primary ovarian failure associated with elevated FSH levels.
• Untreated thyroid or adrenal disorders.
• Infertility caused by conditions other than ovulation disorders.

In men, it should not be used in cases of:

• Prostate or testicular cancer.
• Normal gonadotropin levels indicating normal pituitary function.
• Primary testicular failure associated with elevated gonadotropin levels.
• Infertility unrelated to hypogonadotropic hypogonadism.
• Thyroid or adrenal dysfunction, hyperprolactinemia, and pituitary or hypothalamic tumours should be appropriately evaluated and treated before starting therapy.

✔️ Pregnancy & Lactation

Gonagen has no indicated use during pregnancy or breastfeeding. Pregnancy should be excluded before treatment in women.

✔️ Method of Administration

Gonagen is administered by intramuscular or subcutaneous injection by a trained healthcare professional or according to the specialist's instructions.

Patient assessment before treatment

In women:

• A thorough gynecological and hormonal assessment should be performed before treatment.
• Uterine and fallopian tube abnormalities should be evaluated when appropriate.
• Ovulation status should be assessed, and primary ovarian failure should be excluded.
• Pregnancy must be ruled out before treatment.
• Abnormal uterine bleeding requires investigation before therapy begins.

In men:

• Hormonal testing should confirm hypogonadotropic hypogonadism.
• Testosterone and gonadotropin levels should be assessed.
• The cause of impaired sperm production should be evaluated before treatment.

✔️ Storage:

• Store refrigerated at 2°C–8°C and do not freeze.
• The product may be stored below 25°C for a single period of no more than three months, if permitted by its product instructions.
• Protect from light and moisture.
• Use the reconstituted solution immediately after opening the vial's rubber stopper.
• Discard any unused solution and keep the medicine out of reach of children.