Navigo 40 Infusion | 40mg Vial

✔️ Common Side Effects

• Fatigue, headache, rash, diarrhea, nausea, cough
• Musculoskeletal pain, back pain, pruritus, dyspnea, URTI
• Decreased appetite, abdominal pain, constipation, fever

✔️ Pregnancy & Lactation

• May harm the fetus; advise effective contraception during treatment and for 5 months post-therapy.
• Unknown if nivolumab is excreted in breast milk; breastfeeding decisions should consider the potential risks and benefits.

✔️ Dosage & Administration

Nivolumab is administered via intravenous infusion. The dosage and schedule vary by indication and may be used alone or in combination with ipilimumab, chemotherapy, or targeted therapy. Common regimens include:

• Monotherapy: 240 mg every 2 weeks or 480 mg every 4 weeks
• With ipilimumab: Dose varies by cancer type and patient body weight
• With chemotherapy or cabozantinib: Follow the specific regimen as per the indication

Infusions are given over 30 minutes using a sterile, low protein-binding filter.

Preparation
Dilute with 0.9% Sodium Chloride or 5% Dextrose to a final concentration of 1–10 mg/mL. Do not exceed 160 mL total infusion volume (or 4 mL/kg in patients under 40 kg). Mix gently—do not shake. Administer within 8 hours at room temperature or store up to 7 days at 2–8°C protected from light.

• Pediatric: Not established in patients under 12 years (mCRC) or under 18 for other uses.
• Geriatric: No significant differences in safety or efficacy compared to younger patients.

✔️ Precautions & Warnings

• Monitor for immune-related adverse events affecting the lungs, liver, endocrine organs, skin, and kidneys.
• Regularly assess liver function, renal function, and thyroid hormones.
• Interrupt or discontinue treatment depending on the severity of adverse reactions.
• Watch for infusion reactions; manage accordingly.
• Increased risk of complications post-allogeneic HSCT.
• Contraindicated with thalidomide analogs in multiple myeloma outside clinical trials.

✔️ Storage

Keep refrigerated at 2°C to 8°C. Do not freeze. Protect from light and keep out of children's reach.