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👁️ 4383 বার দেখা হয়েছে
Enliven 100mg Cap 4pcs
Imatinib is a tyrosine kinase inhibitor targeting Bcr-Abl kinase, as well as other receptor tyrosine kinases (e.g., Kit, PDGFR-alpha/beta). It works by:
- Blocking cellular events mediated by these kinases.
- Reducing tumor proliferation and survival.
- Imatinib is absorbed well orally, with peak levels in 2–4 hours.
- Bioavailability: 98%.
- Plasma protein binding: ~95%.
- Metabolized by CYP3A4, with a minor role of CYP1A2, CYP2D6, CYP2C9, and CYP2C19.
- Main active metabolite: N-demethylated derivative.
- Predominantly eliminated in feces (~68%) and urine (~13%) as metabolites.
- Half-life: Imatinib ~18 hours; metabolite ~40 hours.
অফার মূল্য: ৳ 480
MRP:
৳
505
5%
ছাড়
১০০% অরিজিনাল পণ্যের নিশ্চয়তা
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Cash on Delivery - All over Bangladesh
Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
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১০০% অরিজিনাল পণ্যের নিশ্চয়তা
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
- ফ্রি ডেলিভারিঃ - ১৪৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ৪৯৯৯ টাকা+ অর্ডারে, ঢাকার
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📲 মোবাইল অ্যাপ অর্ডারে সাশ্রয় বেশী
✅ বিবরণ:
Enliven is indicated for the following conditions:
- Newly diagnosed adult and pediatric patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in the chronic phase.
- Adult patients with Ph+ CML in blast crisis, accelerated phase, or chronic phase after interferon-alpha therapy failure.
- Adults with relapsed/refractory Ph+ acute lymphoblastic leukemia (Ph+ ALL).
- Pediatric patients with newly diagnosed Ph+ ALL in combination with chemotherapy.
- Adults with myelodysplastic/myeloproliferative diseases associated with PDGFR gene rearrangements.
- Adults with aggressive systemic mastocytosis without D816V c-Kit mutation or with unknown c-Kit mutational status.
- Adults with hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia (CEL) with FIP1L1-PDGFRa fusion kinase or negative/unknown status.
- Adults with unresectable, recurrent, or metastatic dermatofibrosarcoma protuberans.
- Patients with Kit (CD117)-positive unresectable/metastatic gastrointestinal stromal tumors (GIST).
- Adjuvant treatment in adult patients following complete resection of Kit (CD117)-positive GIST.
প্রাসঙ্গিক পণ্য
একই জেনেরিকের বিকল্প পণ্য, গ্রাহকের আগ্রহ অনুযায়ী সাজানো
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কীভাবে অর্ডার করবেন?কীভাবে অর্ডার করবেন?
How to Orderওয়েবসাইট থেকে অর্ডার করার সহজ ভিডিও গাইড।
অ্যাপ থেকে অর্ডারের সহজ ভিডিও গাইড
অ্যাপ ডাউনলোডePharma অ্যাপ ডাউনলোড বিস্তারিত গাইড ›অ্যাপে অর্ডারের বিস্তারিত গাইডসম্পর্কিত লেখা
✔️ Side Effects of Imatinib
- Common: Fluid retention, cytopenias (anemia, neutropenia), gastrointestinal symptoms (nausea, vomiting, diarrhea).
- Serious: Congestive heart failure, hepatotoxicity, hemorrhage, dermatologic reactions (e.g., Stevens-Johnson syndrome), and renal toxicity.
✔️ Overdose Effects
Symptoms may include nausea, vomiting, gastrointestinal pain, edema, cytopenias, or increased bilirubin. Symptomatic treatment and monitoring are required.
✔️ Dosage & Administration of Imatinib
- Take with food and a large glass of water. Tablets may be dissolved in water/apple juice if needed.
- Doses vary by condition, ranging from 100 mg to 800 mg daily, with some conditions requiring twice-daily dosing.
✔️ Interactions
- CYP3A4 Inducers: May reduce imatinib levels (e.g., rifampin, phenytoin).
- CYP3A4 Inhibitors: May increase imatinib levels (e.g., ketoconazole, grapefruit juice).
- CYP3A4 Substrates: Caution with narrow therapeutic index drugs (e.g., certain calcium channel blockers, statins).
- Warfarin: Prefer heparin over warfarin.
✔️ Precautions & Warnings
- Monitor for fluid retention, hepatotoxicity, and cytopenias.
- Avoid use during pregnancy unless necessary; advise effective contraception.
- Breastfeeding is not recommended.
- Monitor growth in children; potential growth retardation has been reported.
- Caution patients about operating machinery or driving.
✔️ Storage Conditions
- Store below 30°C, in a cool and dry place, away from light and moisture.
- Keep out of the reach of children.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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