Panpro 40 | 10 Tablets

✔️ Dosage & Administration | Panpro 40

Controlled-release: Take on an empty stomach, 1 hour before meals. Swallow whole; do not chew or crush.

Standard-release: Can be taken with or without food.

Erosive esophagitis: 40 mg once daily for 8–16 weeks; maintenance 40 mg once daily.

GERD (short-term IV): 40 mg IV once daily for 7–10 days, switch to oral when possible.

Zollinger-Ellison syndrome: 40 mg once daily PO; up to 240 mg/day in some cases. IV: 80 mg every 8–12 hours, up to 7 days.

Duodenal ulcer: 40 mg once daily for 2–4 weeks.

Gastric ulcer: 40 mg once daily for 4–8 weeks.

Pediatric Dose:

<5 years: Safety not established.

5 years (15–40 kg): 20 mg once daily for up to 8 weeks.

≥40 kg: 40 mg once daily for up to 8 weeks.

Elderly & Renal Impairment: No dosage adjustment usually needed.
Hepatic Impairment: Max 20 mg/day or 40 mg on alternate days.

✔️ Side Effects | Panpro 40

Headache (>4%), abdominal pain (4%), chest pain (4%), diarrhea (4%), rash/pruritus (4%), vomiting (>4%), constipation (<4%), facial/generalized edema (<4%)

Other possible: Angioedema, atrophic gastritis, optic neuropathy, hepatocellular damage, interstitial nephritis, pancreatitis, pancytopenia, rhabdomyolysis, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme

✔️ Contraindications:

• Concomitant use with rilpivirine, atazanavir, or nelfinavir
• Lactation

✔️ Precautions & Warnings

• Rule out gastric malignancy before therapy.
• Monitor magnesium levels during prolonged use.
• Zinc supplementation may be needed in at-risk patients receiving IV therapy.
• Pregnancy: Data show no significant risk; use only if necessary.
• Lactation: Pantoprazole is excreted in breast milk; use caution.

✔️ Drug Interactions

• May increase digoxin toxicity.
• Risk of hypomagnesemia with diuretics.
• May increase warfarin INR and prothrombin time.
• Can raise serum concentrations of methotrexate and saquinavir.
• Delayed absorption of sucralfate, ketoconazole, and itraconazole.
• May decrease efficacy of rilpivirine, atazanavir, and nelfinavir (potentially fatal).