Inpro 40 | 10pcs

✔️ Composition

Omeprazole

✔️ Dosage & Administration: Omeprazole 40 mg

Oral:

Gastric/Duodenal Ulcer: 20 mg once daily for 4–8 weeks (increase to 40 mg if necessary).

NSAID-Associated Ulcer: 20 mg once daily for 4–8 weeks; same dose for prevention.

GERD/Reflux Esophagitis: 20 mg once daily for 4–8 weeks; refractory cases may need 40 mg daily.

Long-Term Acid Reflux Management: 10–20 mg daily.

Acid Dyspepsia: 10–20 mg daily for 2–4 weeks.

Acid Aspiration Prophylaxis: 40 mg the evening before, then 40 mg 2–6 hours before surgery.

Zollinger–Ellison Syndrome: Start at 60 mg daily (may increase up to 120 mg in divided doses).

H. pylori Eradication: 20 mg twice daily with antibiotics for 7 days (Amoxicillin/Metronidazole or Clarithromycin combinations).

Pediatric (≥1 year):

10–20 kg: 10–20 mg daily for 4–12 weeks

20 kg: 20–40 mg daily for 4–12 weeks

✔️ Side Effect

Generally well tolerated.
Common: Headache, diarrhea, nausea, flatulence, constipation, abdominal discomfort.
Occasional: Rash, urticaria, dizziness, insomnia, or mild edema.
Rare: Hepatitis, pancreatitis, alopecia, photosensitivity, interstitial nephritis, or hematologic abnormalities.
Most adverse effects are mild and reversible upon discontinuation.

✔️ Drug Interactions

May reduce absorption of ketoconazole and similar drugs.

Can delay metabolism of diazepam, phenytoin, and warfarin—monitor closely.

Clarithromycin increases Omeprazole plasma levels (beneficial in H. pylori therapy).

Avoid combining with clopidogrel due to reduced antiplatelet effect.

May slightly increase digoxin bioavailability (≈10%).

No significant interaction with amoxicillin, caffeine, or NSAIDs.

✔️ Contraindications:

Hypersensitivity to Omeprazole or any component.

Exclude malignancy before starting treatment for gastric ulcers, as Omeprazole may mask symptoms.

✔️ Pregnancy & Lactation

Studies show no harmful effects during pregnancy.

Safety during breastfeeding is not established — use only if necessary

✔️ Precautions & Warnings

• Avoid co-administration with clopidogrel.
• Long-term PPI use may increase the risk of osteoporosis-related fractures.
• Atrophic gastritis and vitamin B12 deficiency may occur with prolonged therapy.
• Use with methotrexate may enhance toxicity.

✔️ Storage:

Store in a cool, dry place, protected from light and heat.
Keep out of the reach of children.