Inpro 20 | 10pcs

✔️ Inpro is indicated for the treatment and prevention of the following acid-related disorders:

• Gastric and duodenal ulcers
• NSAID-induced gastric and duodenal ulcers
• Prophylaxis in patients with a history of NSAID-associated ulcers
• Gastroesophageal reflux disease (GERD)
• Long-term management of acid reflux disorders
• Acid-related dyspepsia
• Severe ulcerative reflux esophagitis
• Prevention of acid aspiration during general anesthesia
• Zollinger–Ellison syndrome
• Peptic ulcers associated with Helicobacter pylori infection

✔️ Side Effects

Generally mild and reversible. Reported adverse effects include:

Common: Headache, diarrhea, constipation, nausea, abdominal pain, flatulence.

Skin: Rash, urticaria, pruritus, photosensitivity, erythema multiforme, alopecia.

Neurological: Dizziness, somnolence, insomnia, vertigo, paresthesia, confusion, agitation, or hallucinations (mostly in severely ill patients).

Hepatic: Elevated liver enzymes, hepatitis (with or without jaundice), and rare hepatic failure.

Other: Arthralgia, myalgia, gynecomastia, edema, leukopenia, thrombocytopenia, anaphylaxis, bronchospasm, fever, malaise.

✔️ Interaction

• Reduced absorption of ketoconazole due to decreased gastric acidity.
• May delay elimination of diazepam, phenytoin, and warfarin; monitor when co-administered.
• No significant interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids.
• Clarithromycin increases plasma levels of both drugs — beneficial in H. pylori eradication.
• Digoxin bioavailability increases by about 10%.
• No effect from food or alcohol.
• Avoid concomitant use with clopidogrel, as it reduces its antiplatelet efficacy.

✔️ Contraindications:

• Known hypersensitivity to omeprazole or any component of the formulation.
• Exclude gastric malignancy before initiating treatment, as omeprazole may mask symptoms and delay diagnosis.

✔️ Pregnancy & Lactation

Studies show no harmful effects of omeprazole on pregnancy or fetal health; may be used during pregnancy if clearly indicated.

Uncertain if excreted in breast milk; discontinue breastfeeding if omeprazole use is essential.

Safety in children under 18 years not fully established.

✔️ Precautions & Warnings

• Avoid use with clopidogrel due to reduced antiplatelet activity.
• Long-term PPI therapy may increase the risk of osteoporosis-related fractures (hip, wrist, spine).
• Atrophic gastritis has been observed in long-term users.
• Concomitant use with methotrexate may increase methotrexate toxicity; monitor closely.

✔️ Storage:

Store in a cool, dry place, away from light and heat.
Keep out of reach of children.