Numira 10 | 1 Strip | 15pcs

✔️ Composition

Mirogabalin Besylate

✔️ Pharmacology

Mirogabalin belongs to the gamma-aminobutyric acid derivative class. It selectively binds to α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and neurotransmitter release at presynaptic nerve endings. This mechanism decreases central nervous system (CNS) hyperexcitability, thereby alleviating neuropathic pain.

Absorption: Rapid after oral administration (Tmax: 0.5–1.5 hrs)

Protein binding: ~25% (low)

Distribution volume: 64–88 L

Elimination: Mainly excreted unchanged (61–72%) via the kidneys; 13–20% metabolized by UGT enzymes

Half-life: 2–4.9 hours

Excretion: ~99% through urine, ~1% via feces

✔️ Side Effect

Common: Drowsiness, dizziness, edema, weight gain

Serious (rare):

Severe dizziness, loss of consciousness

Liver dysfunction (jaundice, nausea, fatigue, vomiting)

✔️ Drug Interaction

Cimetidine, Probenecid → may elevate plasma concentration of Mirogabalin.

Alcohol, Lorazepam → can intensify CNS depressant effects (drowsiness, impaired motor skills).

Mirogabalin is a substrate of OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT.

Does not inhibit or induce major CYP450 enzymes.

✔️ Contraindications

Hypersensitivity to Mirogabalin

Patients with mild to moderate hepatic or renal impairment

✔️ Use in Pregnancy & Lactation

• Use only if the potential benefits outweigh risks.
• Animal studies indicate placental transfer and secretion into breast milk.
• Decision on use during pregnancy or breastfeeding should be made carefully in consultation with a doctor.

✔️ Precautions & Warnings

May cause drowsiness, dizziness, blurred vision, or double vision → avoid driving or operating machinery.

Elderly patients are at increased risk of falls and fractures.

May cause weight gain with prolonged use.

Stop immediately if allergic reactions occur.

Dose adjustment required for patients with renal dysfunction.

✔️ Storage:

Store below 30°C, in a cool, dry place, away from light and moisture.

Keep out of reach of children.