Moxigen XG

Moxigen XG is an antibiotic, used in the treatment of bacterial infections of the eye. It relieves the symptoms of the infection by stopping the further growth of the causative microorganisms. Moxigen XG is for external use only. Take it in the dose and duration as advised by your doctor. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. Avoid skipping any doses and finish the full course of treatment even if you feel better. It may cause eye discomfort, dry eyes and burning sensation in the eyes immediately following application. However, these side effects are temporary and usually subside on their own. Inform your doctor if they persist for a longer duration. It may cause short term blurring of vision when first used. Use caution before driving or using machines. Do not wear contact lenses while using it.

Uses of Moxigen XG

• Bacterial eye infections

Side effects of Moxigen XG

Common

• Eye discomfort
• Dry eye
• Burning sensation

How to use Moxigen XG

This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.

How Moxigen XG works

Moxigen XG is an antibiotic. It treats bacterial eye infections by preventing the bacteria from dividing and repairing. It does so stopping the action of a bacterial enzyme called DNA-gyrase.

What if you forget to take Moxigen XG?

If you miss a dose of Moxigen XG, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

• You have been prescribed Moxigen XG for the treatment of bacterial infections of the eye.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the medication.
• Do not touch the tip to any surface, or to your eye, to avoid contamination.
• Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
• It may cause short term blurring of vision when first used. Use caution before driving or using machines.
• Do not wear contact lenses until your infection clears up.
• Make sure to use within 4 weeks of opening the medication.

Brief Description

Indication

Bacterial Conjunctivitis. This drug is indicated to increase tear production in patients whose tear production is suppressed due to ocular inflammation associated with dry eye syndrome (keratoconjunctivitis sicca).

Adult Dose

Ophthalmic Bacterial conjunctivitis Adult: As 0.5% soln: Instill 1 drop into the affected eye(s) bid-tid for 7 days. It can be used concomitantly with artificial tears, allowing a 15 minute interval between products.

Child Dose

Ophthalmic Bacterial conjunctivitis Child: >1 yr: Instill 1 drop into the affected eye(s) tid for 7 days.

Contraindication

Patients with a history of hypersensitivity to Moxifloxacin, to other Quinolones or to any of the components in this medication

Mode of Action

Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.

Precaution

As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. To prevent contamination do not touch the tip of the dropper to eye, eyelid or any surface of of the affected eye. Keep the bottle tightly closed after use. Lactation: Unknown whether drug is excreted in breast milk; use with caution

Side Effect

1-10% Conjunctivitis,Dry eye,Fever,Increased cough,Infection,Ocular discomfort,Ocular hyperemia,Ocular pain,Ocular pruritus,Otitis media.Pharyngitis,Rash,Rhinitis,Subconjunctival hemorrhage.Tearing

Interaction

Additive effect on QT interval prolongation w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Decreased absorption and bioavailability w/ Al- or Mg-containing antacids, or Fe or Zn preparations. Concomitant use of corticosteroids increases the risk of severe tendon disorders esp in elderly (>60 yr). Decreased absorption w/ sucralfate or didanosine. Potentially Fatal: Concurrent use of class Ia (e.g. quinidine, procainamide) or III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents) may cause additive effect on QT interval prolongation.