Ivtin 6

✔️ Generic Name:

Ivermectin

✔️ Side Effects

Strongyloidiasis:
Reported adverse reactions include fatigue, abdominal pain, anorexia, constipation, diarrhea, nausea, vomiting, dizziness, somnolence, vertigo, tremor, pruritus, rash, and urticaria.

Onchocerciasis:
Common reactions include joint pain, lymph node enlargement and tenderness, pruritus, skin rashes, edema, fever, and ocular symptoms such as conjunctivitis, keratitis, uveitis, and eyelid edema. These reactions are generally mild to moderate and resolve without corticosteroid therapy. Rarely reported reactions include hypotension, worsening asthma, Stevens–Johnson syndrome, and toxic epidermal necrolysis.

✔️ Dosage & Administration of Ivermectin Tablet

For Treatment (if COVIO positive):

Ivermectin 6 mg: 2 tablets once daily for 5 days (2+0+0)

For Prophylaxis:
A single dose on Day 1 and the same dose repeated on Day 7, based on body weight:

15–24 kg: 1 tablet of 3 mg

25–35 kg: 1 tablet of 6 mg

36–50 kg: 1 tablet of 6 mg + 1 tablet of 3 mg

51–65 kg: 2 tablets of 6 mg

66–79 kg: 2 tablets of 6 mg + 1 tablet of 3 mg

≥80 kg: 3 tablets of 6 mg

Strongyloidiasis:
The recommended dose is a single oral dose of approximately 200 mcg/kg, taken on an empty stomach with water. Additional doses are usually not required, but follow-up stool examinations are recommended to confirm eradication.

Strongyloidiasis Dose Guide:

15–24 kg: 3 mg

25–35 kg: 6 mg

36–50 kg: 9 mg

51–65 kg: 12 mg

66–79 kg: 15 mg

≥80 kg: 200 mcg/kg

Onchocerciasis:
The recommended dose is approximately 150 mcg/kg as a single oral dose on an empty stomach. The standard dosing interval is 12 months, although retreatment may be considered as early as every 3 months in selected cases.

Onchocerciasis Dose Guide:

15–25 kg: 3 mg

26–44 kg: 6 mg

45–64 kg: 9 mg

65–84 kg: 12 mg

≥85 kg: 150 mcg/kg

✔️ Drug Interactions | Ivermectin

Rare post-marketing reports have described increased International Normalized Ratio (INR) when Ivtin is administered concomitantly with warfarin.

✔️ Contraindications | Ivermectin

Ivtin is contraindicated in patients with known hypersensitivity to ivermectin or any component of the formulation.

✔️ Pregnancy & Lactation | Ivermectin

Pregnancy:
Category C. Adequate and well-controlled studies in pregnant women are lacking. Ivtin should not be used during pregnancy unless the potential benefit outweighs the risk.

Lactation:
Ivermectin is excreted into breast milk in low concentrations. Treatment during breastfeeding should be considered only if delaying therapy poses a greater risk to the mother than potential exposure to the infant.

✔️ Precautions & Warnings

Patients treated for onchocerciasis may experience inflammatory reactions (Mazzotti reaction) due to the death of microfilariae, including fever, hypotension, edema, and skin reactions. Supportive management may include hydration, corticosteroids, antihistamines, or aspirin. Rare cases of severe encephalopathy have been reported in patients co-infected with Loa loa, presenting with neurological symptoms such as confusion, altered consciousness, or coma.

✔️ Storage:

Store in a dry place below 30°C, protected from light. Keep out of reach of children.