Tridopa 50mg+12.5mg +200mg Tablet | 1 Strip

✔️ Side Effects | Tridopa 50

Very Common (>10%)

Dyskinesia, nausea, diarrhea, hyperkinesia, urine discoloration.

Common (1–10%)

Dizziness, fatigue, anxiety, insomnia, hallucinations, abdominal pain, constipation, vomiting, dry mouth, increased sweating.

Other Possible Effects

Abnormal dreams, orthostatic hypotension, headache, abnormal voluntary movements, agitation, back pain, dyspnea, blurred vision.

Potentially fatal: Rare cases of rhabdomyolysis reported.

✔️ Dosage & Administration |Tridopa 50

Adult: Oral – Initial dose: 1 tablet daily. Dose should be titrated based on patient response.

Recommended: 1 tablet per administration, maximum 8 tablets/day.

Severe hepatic impairment: Contraindicated.

Pediatric use: Safety and efficacy not established.

Tablets must be swallowed whole, not crushed or chewed.

Can be taken with or without food, but avoid high-protein meals and iron supplements, which reduce absorption.

✔️ Drug Interactions | Tridopa 50

Increased risk of severe postural hypotension with antihypertensives or MAO inhibitors.

Iron salts, phenytoin, and papaverine reduce efficacy of Levodopa.

Dopamine antagonists (e.g., certain antipsychotics) may reduce benefit.

Drugs affecting biliary excretion may raise entacapone levels.

May influence hormonal secretion (decrease prolactin, increase growth hormone).

✔️ Contraindications:

Hypersensitivity to any of the ingredients.

Narrow-angle glaucoma.

History or suspicion of melanoma or undiagnosed skin lesions.

Severe liver dysfunction.

✔️ Precautions & Warnings

• Monitor liver, kidney, hematopoietic, and cardiovascular function during long-term therapy.
• Use with caution in patients with chronic wide-angle glaucoma or biliary obstruction.
• Sudden discontinuation may cause severe withdrawal symptoms (fever, rigidity, confusion).
• Caution advised in pregnancy and lactation (Category C).
• May cause daytime sleepiness, dizziness, and hallucinations; patients should avoid driving until they know how the drug affects them.

✔️ Storage:

Store in a cool, dry place below 30°C.

Protect from light and moisture.

Keep out of the reach of children.