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Biozyl 400 | 1 Strip

Generic: Metronidazole

Type: Tablet

Pack Size: 10 Pcs

Inside susceptible microorganisms, Metronidazole undergoes reductive activation by intracellular electron transport proteins. The resulting reactive intermediates interact with microbial DNA, disrupting its helical structure and causing strand breakage. This leads to inhibition of nucleic acid synthesis and cell death.

Biozyl 400 is active against:

  • Most anaerobic protozoa
  • Some Gram-positive and Gram-negative bacteria
  • Certain facultative anaerobes

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✅ Description:

Biozyl 400 is a broad-spectrum antimicrobial agent effective against bacteria and protozoa. It is widely used to treat infections of the respiratory tract, gastrointestinal system, skin, bones, reproductive organs, and oral cavity. Metronidazole — the active component — acts by damaging the DNA of susceptible microorganisms, resulting in the inhibition of protein synthesis and ultimately cell death.

This medicine is particularly effective against anaerobic bacteria and certain protozoal infections.

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✔️ Biozyl 400 is indicated for the treatment of:
  • Pneumonia and aspiration pneumonia
  • Peritonitis and intra-abdominal infections
  • Septicemia and endocarditis
  • Bone and joint infections
  • Lung abscess, empyema, and meningitis/brain abscess
  • Pelvic infections such as endometritis
  • Gastrointestinal infections:
  • Amoebiasis
  • Giardiasis
  • Peptic ulcer disease (H. pylori infection)
  • Diverticulitis
  • Antibiotic-associated colitis
  • Genitourinary infections:
  • Trichomoniasis
  • Bacterial vaginosis
  • Skin and soft tissue infections:
  • Leg ulcers, pressure sores, fungating tumors, diabetic foot ulcer
  • Oral infections:
  • Acute dental infections
  • Acute necrotizing ulcerative gingivitis
  • Surgical prophylaxis against anaerobic bacterial contamination
✔️ Side Effects
  • Headache
  • Nausea or vomiting
  • Metallic or bitter taste in the mouth
  • Dry mouth
✔️ Dosage | Metronidazole

Adult Dosage

ConditionRecommended DoseDuration / Notes
Amoebiasis800 mg three times daily5 days for intestinal infection; 5–10 days for extra-intestinal infection (Max: 2.4 g/day)
Trichomoniasis2 g single dose OR 200 mg three times daily for 7 days OR 400 mg twice daily for 5–7 daysSexual partners should be treated simultaneously. Treatment may be repeated after 4–6 weeks if necessary.
Giardiasis2 g once daily for 3 days OR 400 mg three times daily for 5 days OR 500 mg twice daily for 7–10 days
Bacterial vaginosis2 g single dose OR 400 mg twice daily for 5–7 days
Acute necrotising ulcerative gingivitis200 mg three times dailyFor 3 days
Anaerobic bacterial infectionsInitial: 800 mg, followed by 400 mg every 8 hours OR 7.5 mg/kg every 6–8 hours (Max: 4 g/day)Duration usually 7 days depending on severity
Prophylaxis (Postoperative anaerobic infections)400 mg every 8 hours, starting 24 hours before surgeryContinue with IV or rectal route postoperatively until oral therapy can resume
H. pylori eradication (Peptic ulcer)400 mg twice daily with another antibiotic and a PPI (or 400 mg three times daily with omeprazole + amoxicillin)For 1 week
Leg ulcers / Pressure sores400 mg three times dailyFor 7 days
Acute dental infections200 mg three times dailyFor 3–7 days
Anaerobic infections (IV)500 mg infused in 100 mL (5 mg/mL) at 5 mL/min every 8 hours OR 15 mg/kg over 1 hr followed by 7.5 mg/kg over 1 hr every 6 hrMax: 4 g/day; switch to oral therapy ASAP
Postoperative prophylaxis (IV)500 mg shortly before surgery and repeated every 8 hr OR 15 mg/kg infused over 30–60 min before operation, then 7.5 mg/kg at 6 and 12 hr after
Hepatic impairment (severe)One-third of the usual dose, once dailyAdjust according to clinical response

 

Pediatric Dosage

ConditionAge GroupRecommended DoseDuration
Amoebiasis1–3 years100–200 mg three times daily5–10 days
 3–7 years100–200 mg four times daily5–10 days
 7–10 years200–400 mg three times daily5–10 days
Trichomoniasis1–10 years40 mg/kg as a single dose OR 15–30 mg/kg/day in 2–3 divided doses (Max: 2 g/dose)7 days
Giardiasis1–3 years500 mg once daily3 days
 3–7 years600–800 mg once daily3 days
 7–10 years1 g once daily3 days
Acute necrotising ulcerative gingivitis1–3 years50 mg three times daily3 days
 3–7 years100 mg twice daily3 days
 7–10 years100 mg three times daily3 days
Anaerobic bacterial infections<8 weeks7.5 mg/kg every 12 hr or 15 mg/kg once dailyUsually 7 days
 8 weeks–12 years7.5 mg/kg every 8 hr or 20–30 mg/kg once daily7 days (based on severity)
Prophylaxis (Postoperative anaerobic infections)<40 weeks10 mg/kg single dose before surgery
 <12 years20–30 mg/kg single dose 1–2 hr before surgery
Anaerobic infections (IV)7.5 mg/kg every 8 hr
✔️ Contraindications:

History of hypersensitivity to metronidazole or other nitroimidazole derivatives. Pregnancy (1st trimester) and lactation.

✔️ Metronidazole Tablets:

Should be taken with food to minimize gastrointestinal discomfort.

✔️ Drug Interactions
  • Concurrent use with disulfiram may cause psychotic reactions.
  • May enhance the effects of oral anticoagulants, increasing the risk of bleeding.
  • Lithium toxicity may occur due to elevated serum lithium levels.
  • May reduce renal clearance and increase the toxicity of 5-fluorouracil.
  • Can raise serum concentrations of ciclosporin and busulfan, leading to potential toxicity.
  • Phenobarbital and phenytoin may enhance the metabolism of metronidazole, lowering its plasma concentration and therapeutic efficacy.
✔️ Precautions
  • Use cautiously in patients with CNS disorders or seizure history; discontinue if any neurological abnormalities develop.
  • Monitor total and differential leukocyte counts before and after treatment in patients with a history of blood dyscrasias.
  • Hepatic impairment: Dose adjustment and plasma monitoring may be necessary in severe cases.
  • Contains sodium — exercise caution in patients predisposed to edema.
  • Prolonged use may lead to fungal or bacterial superinfections.
  • Since metronidazole is excreted in breast milk, its use during lactation is not recommended.
✔️ Storage:

Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.

Frequently Asked Questions (FAQ)

The latest Biozyl 400 | 1 Strip price in Bangladesh is shown on this page. Price may change depending on stock, pack size, and active offers.

Yes, you can order Biozyl 400 | 1 Strip online from ePharma when it is available in stock. Delivery options depend on your location in Bangladesh.

Prescription requirements can vary by product type. Please follow the product label and consult a qualified healthcare professional when needed.

Biozyl 400 | 1 Strip is from Bio-Pharma. Please check the product details section for updated manufacturer and product information.

The listed pack size for Biozyl 400 | 1 Strip is 10 Pcs.
Check our pricing section for Biozyl 400 | 1 Strip price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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