Bacifen 10 | 10pcs

✔️ Dosage & Administration

Adults & Children (≥10 years):
Start with 5 mg three times daily, preferably with or after meals. The dose may be gradually increased according to response and tolerance, not exceeding 100 mg per day.

Children (<10 years):
Initial dose: 2.5 mg (2.5 ml) four times daily, with gradual increments as needed.
Maintenance dose by age:

1–2 years: 10–20 mg (10–20 ml) daily

2–6 years: 20–30 mg (20–30 ml) daily

6–10 years: 30–60 mg (30–60 ml) daily

✔️ Side Effects

Common: Drowsiness, fatigue, dizziness, muscle weakness.
Central Nervous System: Headache, insomnia, confusion, hallucinations, tremor, ataxia, blurred vision, or slurred speech.
Cardiovascular: Low blood pressure, occasional palpitations, or fainting.
Gastrointestinal: Nausea, constipation, dry mouth, abdominal pain, or loss of appetite.
Genitourinary: Urinary frequency or retention, impotence, or nocturia.
Other: Rash, itching, weight gain, excessive sweating, ankle swelling, nasal congestion, hepatic dysfunction, or increased spasticity in rare cases.

Muscle weakness significant enough to hinder movement may occur but typically resolves upon dose adjustment (reducing daytime and increasing nighttime doses).

✔️ Drug Interactions

• CNS depressants (e.g., alcohol, opioids, sedatives): May enhance sedation and increase risk of respiratory depression.
• Antihypertensives: Co-administration can potentiate blood pressure reduction; dosage adjustments may be necessary.
• Tricyclic antidepressants: May intensify Bacifen’s effects, causing excessive muscle hypotonia.
• Levodopa + Carbidopa: Reports of hallucinations, nausea, confusion, and agitation when used together.
• MAO inhibitors: May heighten CNS depressant effects; dosage adjustment recommended.
• Neuromuscular blocking agents or magnesium sulfate: Possible synergistic muscle relaxation—monitor closely.

✔️ Contraindications

Bacifen is contraindicated in individuals with known hypersensitivity to Baclofen or any component of the formulation.

✔️ Use in Pregnancy and Lactation

Pregnancy Category B3: Safety during pregnancy has not been firmly established. Baclofen crosses the placenta; therefore, it should be used only if the expected benefits outweigh potential risks.

Lactation: Small amounts may pass into breast milk but are generally not harmful to infants. Nonetheless, medical advice is recommended before use.

✔️ Precautions and Warnings

• Use lower doses (≈5 mg/day) in patients with renal impairment or those on chronic dialysis.
• Exercise caution in individuals with psychotic disorders, schizophrenia, mood disorders, or confusional states, as Bacifen may exacerbate symptoms.
• For patients with epilepsy, ensure continued anticonvulsant therapy since Bacifen may lower the seizure threshold.
• Use cautiously in those with peptic ulcer disease, stroke, hepatic or renal impairment, or respiratory insufficiency.
• Monitor respiratory and cardiac function in patients with cardiopulmonary diseases.
• In patients with bladder sphincter hypertonia, urinary retention may occur—observe closely.
• Bacifen is not significantly effective post-stroke and may be poorly tolerated in such cases.
• Periodic liver function tests and blood glucose monitoring are advised in patients with liver disease or diabetes.

✔️ Storage:

Store below 30°C, protected from light and moisture.
Keep out of reach of children.