Lizid 400mg Tablet 1 Strip

✔️ Side Effects

• Diarrhea
• Headache
• Nausea
• Other possible reactions:
• Oral or vaginal candidiasis
• Hypertension
• Dyspepsia (indigestion)
• Abdominal pain
• Itching (pruritus)
• Tongue discoloration

✔️ Dosage & Administration

Adult Dosage

Uncomplicated Skin and Skin Structure Infections:
400 mg orally every 12 hours for 10–14 days.

Vancomycin-Resistant Enterococcus faecium Infections:
600 mg orally every 12 hours for 14–28 days.

Methicillin-Resistant Staphylococcus aureus (MRSA) Infections:
600 mg orally every 12 hours for 7–21 days.

Community-Acquired Pneumonia (CAP), Nosocomial Pneumonia, and Complicated Skin Infections:
600 mg orally every 12 hours for 10–14 days.

Elderly Patients:
No dosage adjustment needed.

Hepatic Impairment (Mild to Moderate):
No dosage adjustment needed.

Renal Impairment Dosage

No dosage adjustment is needed for patients with renal impairment.

✔️ Pediatric Dosage

Pneumonia, Complicated Skin Infections, Vancomycin-Resistant Enterococcus faecium:

Birth–11 years: 30 mg/kg/day divided every 8 hours (q8h).

>11 years: 1,200 mg/day, divided every 12 hours (q12h).

Uncomplicated Skin Infections:

Birth–5 years: 30 mg/kg/day q8h.

5–11 years: 20 mg/kg/day q12h.

>11–18 years: 1,200 mg/day q12h.

✔️ Drug Interactions

• Monoamine Oxidase Inhibitor (MAOI) Activity: Lizid is a nonselective, reversible MAOI. It may interact with adrenergic and serotonergic agents, enhancing the pressor response to indirect sympathomimetic agents or vasopressors.
• Serotonin Syndrome Risk: Avoid use with serotonin reuptake inhibitors, tricyclic antidepressants, serotonin receptor agonists (triptans), meperidine, or buspirone unless closely monitored.
• Tyramine Interaction: Avoid large amounts of foods/beverages high in tyramine (e.g., aged cheeses, cured meats).

✔️ Lizid must not be used in patients who:

• Are allergic to linezolid or its components.
• Are taking MAO inhibitors or have taken them in the last 2 weeks (e.g., Phenelzine, Isocarboxazid).
• Have uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, or carcinoid syndrome.
• Are taking adrenergic agents (e.g., Pseudoephedrine), vasopressors (e.g., epinephrine, norepinephrine), dopaminergic agents (e.g., dopamine, dobutamine), or serotonin-modifying drugs as mentioned above.

✔️ Pregnancy & Lactation

• Pregnancy: Limited data show no major birth defect risks, but Lizid should only be used if the potential benefit justifies the risk.
• Lactation: Linezolid is present in breast milk. Consider breastfeeding benefits against potential risks. Monitor infants for diarrhea or vomiting.

✔️ Precautions & Warnings

• Blood Monitoring: Weekly complete blood counts are essential, especially if treatment exceeds two weeks or in patients with bone marrow suppression.
• Visual Issues: Prompt ophthalmic evaluation for vision changes (e.g., acuity, color vision, blurriness).
• CDAD (Clostridium difficile-associated diarrhea): Can occur up to two months post-treatment. Discontinue antibiotics not effective against C. difficile if CDAD is suspected.
• Hypertension Risk: Monitor blood pressure closely; avoid it in patients with uncontrolled hypertension or related conditions.
• Metabolic Effects: If nausea, vomiting, or acidosis occurs, seek immediate medical attention. Adjust insulin or hypoglycemic doses if hypoglycemia occurs.

✔️ Storage:

• Keep out of reach of children
• Store at a temperature below 30°C