Amotid Powder for Suspension | 100ml

✔️ Side Effects

Generally mild and transient:

Common: Diarrhea, indigestion, nausea, rash

Rare: Pseudomembranous colitis, exfoliative dermatitis, hypersensitivity vasculitis

Serious (Potentially Fatal): Anaphylaxis, pseudomembranous colitis, severe allergic reactions

✔️ Dosage & Administration

Adults:

General infections: 250 mg three times daily; may increase to 500 mg three times daily for severe infections

Severe/recurrent purulent respiratory infection: 3 g every 12 hours

Otitis media: 1 g three times daily

Pneumonia: 500–1000 mg three times daily

Dental abscess: 3 g, repeated after 10–12 hours

Urinary tract infection: 3 g, repeated after 10–12 hours

Gonorrhea: 2–3 g single dose with 1 g probenecid

H. pylori eradication (triple therapy): 500 mg three times daily with clarithromycin and lansoprazole

Children (up to 10 years):

125 mg three times daily; may increase to 250 mg three times daily for severe infections

Otitis media: 40 mg/kg/day in three divided doses (maximum 3 g daily)

Renal Impairment:
Dosage adjustment may be required.

CrCl 10–30 mL/min: 250–500 mg every 12 hours

CrCl <10 mL/min: 250–500 mg every 24 hours

Hemodialysis: 250–500 mg every 24 hours, plus an additional dose during and after dialysis

✔️ Drug Interactions

• Probenecid: Increases and prolongs serum levels of amoxicillin
• Oral contraceptives: May reduce contraceptive efficacy by altering gut flora
• Allopurinol: Increases risk of allergic skin reactions
• Tetracyclines, macrolides, sulfonamides, and chloramphenicol: May interfere with the bactericidal activity of amoxicillin
• Anticoagulants: May enhance anticoagulant effects

✔️ Contraindications

Hypersensitivity to amoxicillin, other penicillins, or β-lactam antibiotics

✔️ Pregnancy & Lactation

Pregnancy Category B (US FDA): Animal studies show no risk, but human data are limited. Use only if clearly needed.

Lactation: Amoxicillin is excreted in breast milk. Use with caution during breastfeeding.

✔️ Precautions & Warnings

• Caution in patients with renal or hepatic impairment, or a history of allergic reactions to penicillin
• Risk of superinfection with prolonged use; discontinue if secondary infection occurs
• Monitor for signs of hypersensitivity
• Avoid in patients with infectious mononucleosis due to the high risk of rash

✔️ Storage:

Store below 30°C, away from light and moisture. Keep out of reach of children.