Losan 25mg 10pcs

Indications

• Hypertension: Losartan Potassium is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents (eg. thiazide diuretics).
• Renal Protection in Type-2 Diabetic Patients with Proteinuria: Losartan Potassium is indicated to delay the progression of renal disease in hypertensive type-2 diabetics with proteinuria, defined as urinary albumin to creatinine ratio >300 mg/g.

Pharmacology

Losartan Potassium is the primary non-peptide orally dynamic angiotensin II receptor blocker. It ties to the AT1 receptor found in numerous tissues (e.g. vascular smooth muscle, adrenal organ, kidneys, and the heart) and diminishes a few imperative natural activities counting vasoconstriction and the discharge of aldosterone dependable for hypertension.

Dosage & Administration

The usual starting and maintenance dose is 50 mg once daily for most patients. If the antihypertensive effect of using 50 mg once daily is inadequate, 25 mg twice daily is recommended prior to increasing the dose. For patients with intravascular volume depletion (e.g., those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered. Losartan Potassium can be administered once or twice daily. The total daily dose ranges from 25 mg to 100 mg.

Interaction

Rifampicin and fluconazole decrease levels of dynamic metabolite of Losartan Potassium. Concomitant utilize of Losartan Potassium and hydrochlorothiazide may lead to potentiation of the antihypertensive impacts. Concomitant utilization of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increments in serum potassium. The antihypertensive impact of losartan may be weakened by the non-steroidal anti-inflammatory medication indomethacin. The utilize of an ACE inhibitor, angiotensin receptor adversary, an anti-inflammatory medicate, and a thiazide diuretic at the same time increments the chance of renal impedance.

Contraindications

Losartan Potassium is contraindicated in pregnant women and in patients who are hypersensitive to any component of this product. Losartan Potassium should not be administered with Aliskiren in patients with diabetes.

Side Effects

The side effects of the use of Losartan Potassium are mild and transient in nature. The most common side effects are dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection. Other side effects are fatigue, edema, abdominal pain, chest pain, nausea, headache & pharyngitis.

Pregnancy & Lactation

Pregnancy Category D. The risk to the fetus increases if Losartan Potassium is administered during the second or third trimesters of pregnancy. It is not known whether Losartan Potassium is excreted in human milk, as many drugs are excreted in human milk, and because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Precautions & Warnings

The use of Losartan Potassium during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. In patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics), symptomatic hypotension may occur. Plasma concentration of Losartan Potassium is significantly increased in cirrhotic patients. Changes in renal function including renal failure have been reported in renal-impaired patients.

Storage Conditions

keep in a dry place away from light and heat. Keep out of the reach of children.