Alphapress XR 2.5mg Tablet 1 Strip

✔️ Uses of Alphapress XR 2.5

• Hypertension

✔️ Dosage & Administration- Prazosin Tablets

Since tolerance is better when initiated at a low dose, therapy should start with the lowest effective dose and be adjusted based on the patient’s individual response. Typically, the therapeutic effect is observed within 1 to 14 days at a particular dosage. Once an optimal response is achieved, the dose should be maintained before considering further adjustments.

• Children: Not recommended for those under 12 years due to a lack of established safety.
• Left Ventricular Failure: Not suitable for cases due to mechanical obstruction or recent myocardial infarction.

✔️ For Hypertension

New Patients (Not on Other Antihypertensive Therapy):

• Start with 0.5 mg at bedtime, then 0.5 mg twice or three times daily for 3-7 days.
• If well tolerated, increase to 1 mg twice or three times daily for another 3-7 days.

Gradual dose increments may continue until a maximum daily dose of 20 mg is reached, divided into multiple doses.

Patients on Diuretics (With Uncontrolled Blood Pressure):

• Reduce the diuretic to a maintenance dose before starting Prazosin.
• Initiate with 0.5 mg at bedtime, then 0.5 mg twice or three times daily, followed by gradual increases based on response.

Patients on Other Antihypertensive Medications (With Uncontrolled Blood Pressure):

• Reduce the dose of the existing medication (e.g., beta-blockers, calcium channel blockers, ACE inhibitors).
• Start Prazosin at 0.5 mg at bedtime, then gradually increase based on blood pressure response.

Since combining Prazosin with beta-blockers, calcium antagonists, or ACE inhibitors may significantly lower blood pressure, a low starting dose is strongly recommended.

Patients With Moderate to Severe Kidney Impairment:

• Prazosin does not worsen renal function, but since some patients may respond to lower doses, it is advisable to start at 0.5 mg once daily, with cautious dose escalation.

✔️ For Raynaud’s Phenomenon & Raynaud’s Disease

• Starting dose: 0.5 mg twice daily for 3-7 days.
• Maintenance dose: 1 mg to 2 mg twice daily, with some patients requiring up to 2 mg three times daily.

✔️ For Congestive Heart Failure (CHF)

• Initial dose: 0.5 mg, taken 2-4 times daily.
• Dosage is adjusted based on clinical response, with close monitoring of cardiopulmonary status.
• If needed, the dose can be increased every 2-3 days under medical supervision.
• In severe cases, rapid dose titration over 1-2 days may be necessary.
• Effective doses typically range between 4 mg to 20 mg daily, divided into multiple doses.

✔️ For Benign Prostatic Hyperplasia (BPH)

• Starting dose: 0.5 mg twice daily for 3-7 days.
• Maintenance dose: 2 mg twice daily, based on response.

Daily doses exceeding 4 mg should be used with caution as their safety and efficacy have not been well established.

✔️ Prazosin XR (Extended-Release Tablets)

• Tablets must be swallowed whole and should not be split or chewed.
• Initial therapy for hypertension starts at 2.5 mg once daily.
• The 5 mg dose is not suitable for initial treatment.
• Dose increases should occur gradually over 7-14 days, depending on patient response.
• Doses above 20 mg once daily have not been studied.

✔️ Maintenance Dose for Hypertension

• Adjust dosage as needed, up to 20 mg once daily.
• Patients transitioning from Prazosin immediate-release tablets to Prazosin XR can switch to the equivalent or nearest higher dose (e.g., 4 mg of regular Prazosin = 5 mg of XR).
• Blood pressure should be monitored at the end of the dosing interval to ensure 24-hour control.
• Some patients may require additional dose titration for optimal blood pressure regulation.

✔️ Combination Therapy

Adding a diuretic or another antihypertensive medication to Prazosin has been shown to further lower blood pressure due to an additive hypotensive effect.

✔️ Pregnancy & Lactation:

Prazosin has not shown teratogenic effects in animals, but its safety during pregnancy is not fully established. It has been used in severe hypertension during pregnancy without reported fetal abnormalities. It is excreted in small amounts in breast milk, so caution is advised for nursing mothers.

✔️ Precautions & Warnings:

• Hypertension: A small percentage of patients may experience postural hypotension initially, which can be managed with a low starting dose and gradual titration.
• Left Ventricular Failure: A sudden drop in blood pressure may occur in patients previously treated with diuretics or vasodilators. Fluid retention should be monitored and managed.
• Raynaud’s Phenomenon/Disease & Benign Prostatic Hyperplasia: Blood pressure should be closely monitored, especially in elderly patients or those taking antihypertensives.

✔️ Storage:

Store below 30°C, away from light, and moisture, and out of children's reach.