Uritone 20mg+50mg Tablet 1 Strip

✔️ Adverse Effects

• Common: Headache, drowsiness, nausea, cramps, diarrhea
• Endocrine: Gynaecomastia, menstrual changes, voice deepening, hirsutism, impotence
• Metabolic: Hyperkalemia, hyponatremia, mild acidosis
• Cardiovascular: Risk of arrhythmias from electrolyte imbalance
• Others: Skin rash, mental confusion, dehydration, hypotension, rare vascular complications in the elderly

✔️ Dosage & Administration

Frusemide 20 mg + Spironolactone 50 mg:
1 to 4 tablets daily depending on patient response (Frusemide 20–80 mg, Spironolactone 50–200 mg).

Frusemide 40 mg + Spironolactone 50 mg:
1 to 2 tablets daily for patients needing higher doses (Frusemide 40–80 mg, Spironolactone 50–100 mg).

Not recommended for pediatric use.

Elderly patients may experience slower drug clearance and should be monitored closely.

✔️ Drug Interactions

• Risk of hyperkalemia when combined with ACE inhibitors or potassium supplements.
• Increased digoxin toxicity with spironolactone.
• Hypokalemia risk with corticosteroids.
• Reduced diuretic effect when used with NSAIDs like indomethacin.
• Increased ototoxicity with aminoglycosides.
• Sucralfate may interfere with frusemide’s action

✔️ Contraindications

• Anuria or acute renal failure
• Severely impaired renal function (creatinine clearance <30 mL/min)
• Hyperkalemia
• Addison’s disease
• Known hypersensitivity to spironolactone, frusemide, or sulfonamides

✔️ Pregnancy & Lactation

Pregnancy: Spironolactone may cross the placenta. Furosemide has shown fetal risks in animal studies. Use only if the benefits justify potential fetal risks, and only with adequate contraception in women of childbearing age.

Lactation: Both drugs pass into breast milk. If treatment is necessary, breastfeeding should be stopped.

✔️ Precautions & Warnings

Use with caution in patients prone to electrolyte imbalances, diabetes, hypotension, enlarged prostate, or hypovolemia.

Regular monitoring of electrolytes, renal function, and fluid status is advised.

✔️ Storage Conditions

Store below 30°C in a dry, light-protected place.

Keep out of reach of children.