Metavas MR 35 mg 10Pcs

Metavas MR is an anti-anginal medicine used for treating heart-related chest pain (angina). It prevents new attacks of angina but does not stop an acute attack once it has started. It can be used alone or in combination with some other medicines. Metavas MR should be taken regularly as advised by the doctor. You should take it with or without food and at a fixed time. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. If you stop taking it, your chest pain may come back. You can improve the health of your heart by making some lifestyle changes such as quitting smoking, cutting down on alcohol, eating well, taking regular exercise and managing stress. Some common side effects of this medicine include dizziness, headache, diarrhea, indigestion, rash, and abdominal pain. Talk to your doctor if these effects bother you or do not go away. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly.

Uses of Metavas MR

• Angina (heart-related chest pain)

Side effects of Metavas MR

Common

• Constipation
• Dizziness
• Headache
• Nausea
• Vomiting
• Weakness

How to use Metavas MR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metavas MR may be taken with or without food, but it is better to take it at a fixed time.

How Metavas MR works

Metavas MR is an anti-anginal medication. It decreases the oxygen requirement of the heart by shifting its metabolism from fats to glucose. As a result, the heart works more efficiently.

What if you forget to take Metavas MR?

If you miss a dose of Metavas MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

• Metavas MR prevents new attacks of angina but does not stop an acute attack.
• Does not affect heart rate, blood pressure at rest or during exercise.
• Improves HbA1c and blood sugar levels in diabetes patients.
• Avoid driving or using machinery if you feel dizzy after taking Metavas MR.

Brief Description

Indication

Ischaemic heart disease, Angina pectoris, Coronary heart disease

Administration

Should be taken with food.

Adult Dose

Oral Angina pectoris Adult: 40-60 mg daily in 2-3 divided doses. Modified-release tab: 35 mg bid.

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Contraindicated. 30-60 20 mg bid. Modified-release: 35 mg once daily.

Contraindication

Hypersensitivity to Trimetazidine Dihydrochloride.

Mode of Action

Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.

Precaution

Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended. It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

Side Effect

Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing.

Interaction

MAOIs, nifedipine. May potentiate the effects of other antianginals.