Nocandia 200 Capsule 1 Strip

✔️ Therapeutic Class

Antifungal agents for systemic and superficial mycoses

✔️ Dosage & Administration | Itraconazole Capsule

100 mg & 200 mg Capsules

Non-systemic fungal infections

Vulvovaginal candidiasis: 200 mg twice daily for 1 day

Pityriasis versicolor: 200 mg once daily for 7 days

Tinea corporis / tinea cruris:

100 mg once daily for 15 days or

200 mg once daily for 7 days

Tinea pedis / tinea manuum: 100 mg once daily for 30 days

Oropharyngeal candidiasis:

100 mg once daily for 15 days

Increase to 200 mg once daily for 15 days in AIDS or neutropenic patients

Onychomycosis:

Continuous therapy: 200 mg daily for 3 months, or

Pulse therapy: 200 mg twice daily for 7 days, repeated every 21 days

Fingernails: 2 courses

Toenails: 3 courses

Systemic fungal infections

Aspergillosis: 200 mg once daily for 2–5 months; increase to 200 mg twice daily in invasive disease

Candidiasis: 100–200 mg once daily for 3 weeks to 7 months; increase dose if invasive

Non-meningeal cryptococcosis: 200 mg once daily for 10 weeks

Cryptococcal meningitis: 200 mg twice daily for 2–6 months

Histoplasmosis: 200 mg once or twice daily for 8 months

Maintenance in AIDS: 200 mg once daily until immune recovery

Neutropenia prophylaxis: 200 mg once daily until immune recovery

65 mg & 130 mg Capsules

Dosing follows the same clinical indications as above, with adjusted strengths:

Non-systemic infections: 65–130 mg once or twice daily, depending on condition

Systemic infections: Dose escalation to 130 mg twice daily in invasive disease

Maintenance and prophylaxis: 65 mg twice daily until immune recovery

Dose and duration should be individualized based on clinical response.

50 mg Capsules (Pediatric Use)

Treatment

Children >4 weeks to <12 years:

1.25–2 mg/kg/dose twice daily (maximum initial dose 100 mg)

May increase to 5 mg/kg/dose twice daily in severe infections

Children ≥12 years:

50–100 mg once daily

May increase to 100 mg twice daily if required

Prophylaxis

Children ≥2 years: 2.5 mg/kg once daily (maximum 200 mg/day)

Doses should be adjusted based on therapeutic drug monitoring and rounded to the nearest 50 mg.

✔️ Side Effects

Common adverse effects include nausea, abdominal discomfort, dyspepsia, constipation, headache, dizziness, and elevated liver enzymes. Other reported reactions include menstrual irregularities, allergic skin reactions, hepatitis, cholestatic jaundice, peripheral neuropathy, and rare cases of Stevens–Johnson syndrome. Long-term therapy may result in hypokalemia, edema, and alopecia.

✔️ Pregnancy & Lactation

Itraconazole is contraindicated during pregnancy. Breastfeeding is not recommended during treatment due to potential risk to the infant.

✔️ Interaction

Concurrent use of Nocandia with terfenadine, astemizole, cisapride, simvastatin, oral midazolam, or triazolam is contraindicated. Clinically significant interactions have also been observed with rifampin, phenytoin, phenobarbital, digoxin, and calcium channel blockers. There is no documented experience with overdose.

✔️ Contraindications

Itraconazole is contraindicated in patients with hypersensitivity to the drug or its components. Use is not recommended in patients with severe hepatic impairment or in those receiving rifampin due to altered metabolism.

✔️ Precautions & Warnings

Absorption may be reduced in patients with low gastric acidity

Antacids should be taken at least 2 hours after Nocandia

The capsule should be taken after a full meal

Liver function monitoring is recommended for treatments exceeding one month

✔️ Storage:

Store below 25°C in a cool, dry place, protected from light. Keep out of reach of children.