Diphedan 100 | 1 Strip

✔️ Uses of Diphedan 100

• Epilepsy/Seizures

✔️ How does Diphedan 100 work?

Diphedan is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

✔️ Dosage and Administration

For Adults:

• Usual Dose:
  • Initial: 200 mg daily (2 tablets).
  • Maintenance: 300–400 mg/day (maximum of 600 mg/day) in divided doses.
  • For Naive Patients: 1 tablet (100 mg) three times daily or as directed by a physician.

For Children:

• Initial Dose: 5 mg/kg per day, divided into 2–3 doses.
• Maintenance Dose: 4–8 mg/kg per day (maximum: 300 mg daily).
• Children Over 6 Years: Require the minimum adult dose (300 mg/day).

✔️ Side Effects of Diphedan 100

Common:

• Skin rashes (disappear after discontinuation).
• Insomnia, dizziness, slurred speech, headache, transient nervousness.

Serious:

• Hyperglycemia due to inhibition of insulin release.

✔️ Drug Interactions

Phenytoin exhibits extensive interactions:

Potentiation:

• Enhances toxic effects of paracetamol and lithium.
• Effects may be increased with other sedatives or alcohol.

Increased Serum Levels:

• With drugs like cimetidine, omeprazole, fluconazole, methylphenidate, and SSRIs.

Decreased Serum Levels:

• With carbamazepine, rifampin, ciprofloxacin, and folic acid.

Specific Notable Interactions:

• Valproic Acid: May displace phenytoin from protein-binding sites, altering its serum concentration.
• Warfarin: Initial increase in anticoagulation effects, followed by inhibition.

✔️ Contraindications

Known hypersensitivity to Phenytoin or other hydantoins.

✔️ Precautions & Warnings

Skin Reactions:

• Discontinue use if a rash develops.

Long-Term Use:

• Regular blood tests are advised during prolonged therapy.

Pregnancy and Nursing Mothers:

• Use with caution due to potential effects on fetal and infant health.

Hyperglycemia Risk:

• Monitor blood sugar levels, especially in diabetic patients.

✔️ Storage Conditions

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.