Cloma 2 | 1 Strip

✔️ Dosage

Adult Dose:

Epilepsy: Start with 1 mg nightly for 4 days, gradually increasing over 2–4 weeks to a maintenance dose of 4–8 mg/day (maximum 20 mg/day).

Panic disorder: Begin with 0.25 mg twice daily, increasing to 1 mg/day after 3 days (maximum 4 mg/day).

IV (Status epilepticus): 1 mg slow IV injection over at least 2 minutes; may repeat if needed (max 20 mg).

Elderly: Start low (0.5 mg nightly for 4 days) and adjust cautiously.

Pediatric Dose:

Epilepsy (oral): Start with 0.01–0.03 mg/kg/day in 2–3 divided doses (max 0.05 mg/kg/day). Increase by 0.25–0.5 mg every 3 days until control is achieved. Maintenance: 0.1–0.2 mg/kg/day in 3 divided doses (max 0.2 mg/kg/day).

IV (Status epilepticus): 500 mcg slow IV injection or infusion.

Hepatic Impairment:
Dose adjustment may be required in patients with liver dysfunction.

✔️ Administration:

Take Cloma 2 exactly as prescribed by your physician. Swallow the tablet whole with water — do not chew, crush, or break it. It may be taken with or without food, preferably at a fixed time each day.

✔️ Missed Dose

If you forget a dose, take it as soon as possible. If it’s nearly time for your next dose, skip the missed one. Never double the dose to make up for a missed tablet.

✔️ Cloma 2 may cause additive CNS depression when used with:

Tricyclic antidepressants (TCAs)

MAO inhibitors

Sedatives, hypnotics, barbiturates, antipsychotics, or opioid analgesics

It may also increase serum phenytoin levels, requiring dosage adjustments.

✔️ Cloma 2 should not be used in patients with:

• Hypersensitivity to benzodiazepines
• Severe pulmonary insufficiency
• Acute narrow-angle glaucoma

✔️ Side Effects

• Drowsiness, dizziness, fatigue, impaired coordination
• Depression, confusion, memory problems
• Upper respiratory infections, cough, rhinitis
• Urinary frequency, decreased libido, impotence
• Increased salivation, respiratory difficulty (especially in children)
• Worsening of tonic-clonic seizures
• Rarely, blood disorders or coma in overdose

✔️ Pregnancy & Lactation

Use during pregnancy is not recommended, as it may cause fetal harm, respiratory depression, or withdrawal symptoms in newborns.

Small amounts may pass into breast milk, so use cautiously during breastfeeding.

Potential long-term effects on neurodevelopment have been noted in animal studies.

✔️ Precautions & Warnings

• Use cautiously in elderly, neonates, or those with renal/hepatic impairment or chronic lung disease.
• Avoid abrupt withdrawal — stopping suddenly can cause anxiety, agitation, tremor, sweating, confusion, and flu-like symptoms.
• May cause drowsiness or dizziness — avoid driving or operating machinery.
• Avoid alcohol as it enhances sedative effects.
• Regularly monitor for mood changes, aggression, or worsening depression.
• Not recommended during pregnancy or lactation unless absolutely necessary.

✔️ Storage:

Store in a cool and dry place, protected from light.