Lubicon 24mcg Capsule 10Pcs

Lubicon 24 is a prescription medicine used to treat constipation and irritable bowel syndrome (symptoms include abdominal pain, cramping, bloating, and diarrhea or constipation). It works by increasing the secretion of fluids in the intestine, thereby making the stool soft and easier to pass. Lubicon 24 is taken after meals to avoid nausea in a dose and duration as advised by the doctor. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are nausea, diarrhea, headache, abdominal pain, and flatulence. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine may cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. Lifestyle modifications like having fiber rich diet and regular exercise can help you to get better results. Before taking this medicine, you should let your doctor know if you have liver and kidney problems. Pregnant or breastfeeding women should also consult their doctor. You may have difficulty in breathing after taking this medicine which generally resolves within three hours but may recur with repeat dosing.

Uses of Lubicon 24

• Constipation
• Irritable bowel syndrome

Side effects of Lubicon 24

Common

• Nausea
• Headache
• Abdominal pain
• Abdominal distension
• Diarrhea
• Flatulence

How to use Lubicon 24

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lubicon 24 is to be taken with food.

How Lubicon 24 works

Lubicon 24 increases the secretion of fluids in the intestine, which in turn increases the motility of the intestine, thereby making the stool soft and easier to pass.

What if you forget to take Lubicon 24?

If you miss a dose of Lubicon 24, skip it and continue with your normal schedule. Do not double the dose.

Quick Tips

• Lubiprostone should preferably be taken with meals to reduce symptoms of nausea.
• Seek medical attention if you experience severe diarrhea, breathlessness (dyspnea) or difficulty in breathing, chest pain, tightness in chest during treatment.
• You should be thoroughly examined to confirm the absence of obstruction (e.g. gall stones, hernia, Crohn's disease, diverticulitis, polyps, impacted bowel movement etc.) before starting lubiprostone treatment.
• Lubiprostone is not recommended in children under 18 years of age.
• Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.

Brief Description

Indication

Irritable Bowel Syndrome with Constipation (IBS-C), Chronic idiopathic constipation, Opioid-induced Constipation (OIC) in adults with chronic non-cancer pain

Administration

Should be taken with food.

Adult Dose

Oral Chronic idiopathic constipation Adult: 24 mcg bid daily. Irritable Bowel Syndrome With Constipation 8 mcg twice daily. Opioid-Induced Constipation Treatment in patients with chronic noncancer pain 24 mcg bid daily. Hepatic impairment Mild: Dose adjustment not necessary Moderate (Child-Pugh B): Chronic idiopathic or opioid-induced constipation, 16 mcg PO q12hr; irritable bowel syndrome with constipation (IBS-C), no dosage adjustment required Severe (Child-Pugh C): Chronic idiopathic or opioid-induced constipation, 8 mcg PO q12hr; IBS-C, 8 mcg PO q24hr

Child Dose

Safety and efficacy not established

Contraindication

History of mechanical GI obstruction.

Mode of Action

Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. Lubiprostone acts by specifically activating ClC-2, which is a normal constituent of the apical membrane of the human intestine. By increasing intestinal fluid secretion, Lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation.

Precaution

Safety has not been established in pregnant women. Not to be used in patients with severe diarrhoea. Lactation: Unknown whether drug is excreted in breast milk; because lubiprostone increases fluid secretion in the intestine and intestinal motility, monitor breastfeeding infants for diarrhea

Side Effect

>10% Nausea (29%),Headache (12%),Diarrhea (11%) 1-10% Edema (3%),Chest discomfort (2%),Peripheral edema (1-3%),Fatigue (2%),Dizziness (3%),Flatulence (4-6%),Abdominal distress (3%),Dyspepsia (2%),Xerostomia (1%),Abdominal pain (4-8%),Loose stools (3%)