Prostanil MR 0.4mg Capsule 6pcs

✔️ Key Benefits of Prostanil MR

• Relieves BPH symptoms like frequent or urgent urination.
• Helps empty the bladder.

✔️ Common Side Effects

• Retrograde ejaculation
• Dizziness
• Nasal congestion (stuffy nose)

If side effects persist, consult your doctor immediately.

✔️ Pharmacokinetics

• Absorption: 90% bioavailability when taken orally on an empty stomach.
• Peak Concentration (Tmax):
  • 4-5 hours (fasting)
  • 6-7 hours (with food)
• Protein Binding: 94-99% bound to plasma proteins.
• Metabolism: Extensively metabolized in the liver (CYP450 enzymes), with <10% excreted unchanged in urine.
• Half-life:
  • Immediate-release form: 5-7 hours
  • Modified-release (Prostam capsules):
    • 9-13 hours (healthy individuals)
    • 14-15 hours (BPH patients)

✔️ Dosage & Administration

• Initial dose: Tamsulosin 0.4 mg (one capsule) daily, taken after a meal at night.
• If necessary, increase to 0.8 mg (two capsules) once daily after 2-4 weeks.
• If therapy is interrupted for several days, restart with 0.4 mg once daily.
• The capsule must be swallowed whole with 150 ml water in a standing or sitting position.
• Do not crush or chew to maintain modified release.

⚠ Always follow your doctor’s prescription.

✔️ Quick Tips for Prostanil MR Users

• Take with food for better absorption.
• Avoid driving if you feel dizzy or sleepy.
• Inform your eye doctor before cataract or glaucoma surgery.
• Stay hydrated and avoid caffeine/alcohol before bedtime.

✔️ Drug Interactions

• Other alpha-1 blockers: May cause excessive hypotension.
• No interactions were observed with atenolol, enalapril, or nifedipine.
• Cimetidine: Increases Tamsulosin levels (but no dosage adjustment needed).
• Frusemide: Decreases plasma levels (no dosage adjustment needed).
• Diclofenac & Warfarin: May increase elimination of Tamsulosin.
• No significant hepatic metabolism interactions with amitriptyline, salbutamol, glibenclamide, or finasteride.

✔️ Tamsulosin should not be used in patients with:

• Hypersensitivity to Tamsulosin.
• History of orthostatic hypotension.
• Severe hepatic insufficiency.

✔️ Pregnancy & Lactation

• Not recommended for use in pregnant or lactating women.

✔️ Precautions & Warnings

• Risk of hypotension: May cause a drop in blood pressure, leading to dizziness, weakness, or syncope. Patients should sit or lie down if symptoms occur.
• Driving & Machinery: Patients should avoid hazardous activities (e.g., driving, operating machinery) due to the risk of dizziness.
• Pre-treatment Examination: Other conditions mimicking BPH should be ruled out before starting treatment. A digital rectal exam and Prostate-Specific Antigen (PSA) test should be performed before and during therapy.
• Use in micturition syncope: Not advised due to the risk of fainting.

✔️ Overdose Effects

• Acute overdose may lead to severe hypotension.
• Treatment:
  • Lie the patient down to restore blood pressure.
  • If needed, use volume expanders or vasopressors.
  • Monitor renal function and provide supportive care.
  • Dialysis is unlikely to be effective due to high protein binding.
  • Large overdoses may require gastric lavage, activated charcoal, or osmotic laxatives.

✔️ Storage Condition

Store below 30°C in a cool, dry place, protected from light.