Flacort 6mg Tablet 1 Strip

✔️ Uses of Flacort 6

• Severe allergic reactions
• Allergic conditions
• Asthma
• Cancer
• Rheumatic disorder
• Skin disorders
• Eye disorders

✔️ Dosage & Administration of Flacort 6

Adults

• Acute conditions: Up to 120 mg/day may be required initially.
• Rheumatoid arthritis: Maintenance dose typically ranges between 3–18 mg/day; titrate to the lowest effective dose.
• Bronchial asthma: Acute flare-ups may need 48–72 mg/day, which should be gradually tapered. For chronic asthma, adjust to the lowest effective maintenance dose.
• Other conditions: Doses are based on clinical need and typically converted at a ratio of 5 mg prednisone to 6 mg Deflazacort.

Children

Though clinical exposure in children is limited, dosing guidelines generally fall between 0.25–1.5 mg/kg/day depending on the condition. Alternate-day dosing may be considered to minimize side effects.

• Juvenile arthritis: 0.25–1.0 mg/kg/day (maintenance)
• Nephrotic syndrome: Start at 1.5 mg/kg/day, then taper
• Asthma: Initial dose of 0.25–1.0 mg/kg on alternate days based on potency ratio

Use only under the supervision of a licensed medical practitioner.

• Hepatic Impairment: Monitor drug levels and adjust dosage carefully.
• Renal Impairment: No specific dose adjustment required beyond standard corticosteroid precautions.
• Elderly: Monitor closely as corticosteroid side effects can have more serious consequences.

✔️ Discontinuation

For patients who have been on systemic corticosteroids (approx. 9 mg/day or more) for over 3 weeks, gradual tapering is required to avoid relapse and adrenal insufficiency.

✔️ Possible adverse effects include:

• Gastrointestinal disturbances, electrolyte imbalance, increased infection risk, and delayed wound healing
• Musculoskeletal issues like osteoporosis and myopathy
• Neuropsychiatric symptoms such as mood swings or psychosis
• Endocrine disturbances, including adrenal suppression
• Skin changes like striae, acne, and thinning
• Risk of thromboembolic events and cardiovascular complications, including post-MI myocardial rupture

✔️ Drug Interactions

Flacort is metabolized in the liver. Enzyme inducers like rifampicin, carbamazepine, phenobarbitone, and phenytoin may reduce its effectiveness, requiring dose adjustments.

Enzyme inhibitors such as ketoconazole may increase drug levels, possibly necessitating a lower maintenance dose.

✔️ Contraindications

• Hypersensitivity to Deflazacort or any component of the formulation
• Concurrent use with live virus vaccines

✔️ Pregnancy & Lactation

Pregnancy:

Deflazacort crosses the placenta. Prolonged or repeated use may result in fetal growth restriction. It should be used only when the potential benefits outweigh the risks.

Breastfeeding:

Although no direct data is available for Deflazacort, corticosteroids are excreted in breast milk. Doses up to 50 mg/day are generally considered safe. Higher doses may carry a risk of adrenal suppression in infants, though breastfeeding benefits often outweigh these risks.

✔️ Caution is advised in patients with:

• Cardiovascular issues (heart failure, hypertension, thromboembolism)
• GI conditions (gastritis, ulcerative colitis, diverticulitis, peptic ulcers)
• Diabetes or a family history of diabetes
• Osteoporosis, myasthenia gravis, or renal impairment
• Neuropsychiatric disorders (psychosis, epilepsy)
• Liver dysfunction, hypothyroidism, or cirrhosis
• Ocular herpes simplex due to potential corneal perforation

✔️ Storage

Store below 25°C in a cool, dry location protected from moisture and light. Keep out of children’s reach.