Informet XR 500mg Tablet Pot

✔️ Uses of Informet XR 500

• Type 2 diabetes mellitus

✔️ Dosage & Administration

Take Informet XR 500 exactly as prescribed. Swallow the tablet whole—do not crush or chew. Always take it with food to reduce stomach discomfort.

If you forget a dose, take it as soon as you remember. If it's nearly time for the next dose, skip the missed one—never double the dose.

✔️ Words of Advice:

• Helps control blood sugar and lowers the risk of diabetic complications like heart issues.
• Less likely to cause weight gain or low blood sugar than some other diabetes medications.
• Hypoglycemia can still occur with other diabetic drugs, alcohol, or missed meals—keep a sugar source handy.
• Watch for symptoms like fast breathing, nausea, or abdominal pain, which could signal lactic acidosis, a rare but serious side effect.
• Long-term use may lead to vitamin B12 deficiency—report fatigue, pale skin, or shortness of breath to your doctor.
• Regular blood sugar and kidney monitoring is essential during treatment.

✔️ Side Effects

• Nausea
• Vomiting
• Taste change
• Diarrhea
• Abdominal pain
• Loss of appetite

✔️ How does

Informet XR 500 is a biguanide antidiabetic. It helps lower blood sugar by reducing glucose production in the liver, slowing sugar absorption from the gut, and improving insulin sensitivity.

✔️ Adult Dosage

For Type 2 Diabetes Mellitus:

Conventional (Immediate-Release) Formulation:

Start with 500 mg twice or three times daily, or 850 mg once or twice daily.

Increase gradually to a maximum of 2000 mg/day, adjusting every 1 week.

Maximum dose: 2550 mg/day.

Modified-Release (Extended-Release) Formulation (e.g., Informet XR 500):

Start with 500 mg once daily, preferably at night.

Increase by 500 mg weekly as needed.

Max dose: 2000 mg once daily at night.

If blood sugar is not well-controlled, split dose to 1000 mg twice daily.

Do not exceed 2000 mg/day.

For Polycystic Ovary Syndrome (PCOS):

Week 1: 500 mg once daily (morning)

Week 2: 500 mg twice daily

Then increase to 1.5–1.7 g/day in 2–3 divided doses based on tolerance.

Special Populations:

 Elderly: Use with caution; dose should be adjusted based on renal function. Regular monitoring is required.

Children (10–12 years): Use carefully; monitor growth and puberty as long-term safety data is limited.

Renal Monitoring:

Test GFR before starting and annually if normal

2–4 times/year if near the lower normal range or in the elderly

Discontinue temporarily if renal function worsens

Contraindicated if GFR <30 mL/min

Liver Impairment: Avoid use due to the elevated risk of lactic acidosis.

✔️ Drug Interactions

• Furosemide: No conclusive data on long-term interaction with Informet XR.
• Nifedipine: May increase absorption of Informet XR, though Informet has minimal effect on Nifedipine.
• Cationic Drugs (e.g., Digoxin, Morphine, Vancomycin, etc.): May compete for renal tubular secretion, potentially affecting Informet XR clearance.
• Cimetidine: No significant pharmacokinetic interaction.
• Drugs that can raise blood sugar levels (may reduce Informet's effectiveness):
• Thiazide diuretics, corticosteroids, phenothiazines, thyroid hormones
• Estrogens, oral contraceptives, phenytoin, nicotinic acid
• Sympathomimetics, calcium channel blockers, and isoniazid
• Regular blood glucose monitoring is advised when co-administered with these agents

✔️ Contraindications

Informet XR 500 should not be used in the following conditions:

• Known allergy or hypersensitivity to metformin or excipients.
• Severe renal impairment (GFR <30 mL/min).
• Metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis).
• Conditions affecting kidney function, such as severe dehydration, infections, or shock.
• Diseases causing tissue hypoxia, including:
• Heart or respiratory failure
• Recent heart attack
• Liver failure
• Acute alcohol poisoning or chronic alcoholism

✔️ Pregnancy & Lactation

Pregnancy: Uncontrolled diabetes during pregnancy increases the risk of birth defects and perinatal mortality. Insulin is preferred over metformin for managing blood glucose during pregnancy to minimize fetal risk.

Lactation: Metformin is passed into breast milk, but no harmful effects have been noted in infants. Due to limited data, breastfeeding is not recommended during treatment. The decision should weigh the benefits of breastfeeding against potential risks.

✔️ Precautions & Warnings

• Kidney Function: Since Informet XR is mainly excreted by the kidneys, renal impairment increases the risk of lactic acidosis. Regular monitoring of kidney function is essential.
• Vitamin B12 Deficiency: Long-term use may reduce vitamin B12 absorption. Annual testing is advised.
• Hypoglycemia Risk: Higher risk when used with insulin or insulin secretagogues. Blood sugar monitoring is necessary.
• Surgical or Diagnostic Procedures: Discontinue Informet XR 2–3 days before major surgery or contrast-based imaging. Restart only when renal function is stable.
• Dehydration & Infection: Avoid use during severe infections, trauma, or dehydration to prevent complications.

Drug Interactions:

• Cimetidine: May reduce Informet XR clearance — consider dose adjustment.
• Anticoagulants: Possible interaction requiring monitoring and dosage adjustment.

✔️ Storage Conditions

Store below 30°C, protected from light and moisture

Keep out of reach of children