Dermasol-N Ointment 15gm

Indications of Dermasol-N Ointment

This method is described in-

• In the treatment of refractory eczema in the short term.
• Neurodermatosis.
• Secondary bacterial or fungal infections are present, suspected, or likely to occur in psoriasis (excluding generalized plaque psoriasis).
• Other inflammations are resistant to less active steroids.

Pharmacology of Dermasol-N Ointment

Clobetasol propionate is a powerful corticosteroid. It is used to treat severe inflammatory skin conditions like eczema and psoriasis that do not respond to less potent corticosteroids. The aminoglycoside antibiotic neomycin sulfate is used to treat bacterial infections. Nystatin is an antifungal agent that works by interfering with the cell membranes of fungi and yeast. In general, the mechanism of action of topical steroids like clobetasol is unknown. Clobetasol propionate, on the other hand, is a potent corticosteroid with anti-inflammatory properties. Clobetasol propionate has a nonspecific anti-inflammatory effect on the skin, which is caused by vasoconstriction and decreased collagen synthesis. Neomycin inhibits protein synthesis by binding to ribosomal subunits 30 and 50 in susceptible bacteria. Neomycin can also cause a misreading of the mRNA template's genetic code, resulting in the incorrect amino acids being incorporated into the growing polypeptide chain. Nystatin's role is to bind to sterols in the fungal cell membrane, altering membrane permeability and causing intracellular component leakage.

Dosage & Administration of Dermasol-N Ointment

Adults: 

Apply sparingly to the affected area once or twice daily until the condition improves. In extremely resistant lesions, particularly those with hyperkeratosis, the anti-inflammatory effect of this preparation can be boosted (if necessary) by occluding the treatment area with polythene. Without medical supervision, treatment should not be continued for more than 7 days. If a longer course is required, it is recommended that treatment not be continued for more than 4 weeks without a review of the patient's condition.

Elderly: 

This medication is safe to use for the elderly. Caution should be used when there is a decrease in renal function and significant systemic absorption of Neomycin Sulphate.

Children: 

This medication is safe for children (2 years and older) to take at the same dose as adults. Because there is a risk of increased absorption in very young children, this cream/ointment is not recommended for use in neonates and infants (younger than 2 years).

Interaction of Dermasol-N Ointment

After significant systemic absorption, neomycin sulfate can improve and prolong the respiratory depression caused by neuromuscular blockers. However, if used as directed, systemic exposure to neomycin sulfate should be minimal, and drug interactions should be minimal. There have been no reports of harmful interactions between clobetasol propionate and nystatin.

Contraindications

The drug is contraindicated in patients with rosacea, acne vulgaris, perioral dermatitis, primary viral infections of the skin (such as herpes simplex, and chickenpox), and patients allergic to the preparation.

Side Effects of Dermasol-N Ointment

Like other topical corticosteroids, long-term large-scale use or large-area treatment may lead to adequate systemic absorption, resulting in the characteristics of hypercortisolism. If an occlusive dressing is used, this effect is more likely to occur in infants and children. Long-term and intensive treatment with highly active corticosteroid preparations can cause local atrophic changes in the skin, such as thinning, stretch marks, and superficial vasodilation, especially when the use of occlusive dressings or skin folds is affected. There are reports that topical steroids can cause pigmentation changes and hirsutism.

Pregnancy & Lactation

There is little data to prove the possible effects of topical neomycin on pregnancy and lactation. However, neomycin present in maternal blood can cross the placenta and theoretically can cause risks of fetal toxicity, so it is not recommended to use this preparation during pregnancy and lactation. The safety of clobetasol propionate in nursing mothers has not been established.

Precautions & Warnings

Long-term continuous topical treatment should be avoided as much as possible, especially in infants and children, because adrenal suppression is prone to occur even in the absence of occlusion. If applied to the eyelids, care must be taken to ensure that the preparation does not get into the eyes as it can cause glaucoma. If this medicine gets into your eyes, flush the affected eyes well with plenty of water.

Storage Conditions

Store below 25°C temperature. Do not freeze. Keep out of reach of children.