Dalacin-IM/IV 300 Injection

Indications of Dalacin-IM/IV 300 Injection

Clindamycin has been appeared to be successful within the treatment of the taking after contaminations when caused by helpless anaerobic microbes or vulnerable strains of gram positive microbes such as Streptococci, Staphylococci and Pneumococci; Upper respiratory contaminations, Lower respiratory diseases, Skin and delicate tissue diseases, Bone and joint diseases, Pelvic contaminations, Intra-abdominal contaminations, Septicemia and endocarditis, Dental contaminations. As an elective treatment when utilized in combination with quinine or amodiaquine for the treatment of multi-drug safe Plasmodium falciporum contamination.

Pharmacology of Dalacin-IM/IV 300 Injection

Clindamycin could be a lincosamide anti-microbial utilized within the treatment of contaminations caused by vulnerable microorganisms. Clindamycin could be a semisynthetic anti-microbial determined from lincomycin. Aerobic gram-positive cocci, counting: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase creating strains), Streptococci, Pneumococci. Anaerobic gram-negative bacilli, counting: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore shaping bacilli, counting: Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, counting: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perferinges

Dosage & Administration of Dalacin-IM/IV 300 Injection

Dosage of Clindamycin Capsule:

Serious Infections: 150 mg-300 mg every six hours.

More severe infections: 300 mg-450 mg every six hours.

To avoid the possibility of oesophageal irritation, Clindacin capsules should be taken with a full glass of water.

Several researches has found that Clindamycin 300 mg capsule provides plasma concentration over MIC90 for more than 12 hours. This finding supports the twice-daily dosing of Clindacin 300 mg capsule, particularly in SSTIs & RTIs. However, in case of bone & joint infections, diabetic foot infections dose of Clindamycin should be 300 mg capsule 3-4 times daily.

Dosage of Clindamycin Powder for oral solution:

Serious infections: 8-12 mg/kg/day divided into 3 or 4 equal doses.

Severe infections: 13-16 mg/kg/day divided into 3 or 4 equal doses.

More severe infections: 17-25 mg/kg/day divided into 3 or 4 equal doses.

In pediatric patients weighing 10 kg or less, 1/2 teaspoon (37.5 mg) three times a day should be considered the minimum recommended dose.

Dosage of Clindamycin IV/IM Injection:
Adults-

Serious infections due to aerobic gram-positive cocci and the more susceptible anaerobes: 600-1200 mg/day in 2- 4 equal doses.

More severe infections: 1200-2700 mg/day in 2-4 equal doses.

For more serious infections: these doses may have to be increased. In life-threatening situations due to either aerobes or anaerobes, these doses may be increased.

Doses of as much as 4800 mg daily have been given intravenously to adults. Single intramuscular injections of greater than 600 mg are not recommended.

Neonates (less than 1 month): 15 to 20 mg/kg/day in 3 to 4 equal doses. The lower effective dosage may be adequate for small prematures.

Pediatric patients (1 month of age to 16 years):

20 to 40 mg/kg/day in 3 or 4 equal doses. The higher doses would be used for more severe infections.

Parenteral therapy may be changed to Capsules (clindamycin hydrochloride) when the condition warrants and at the discretion of the physician.

In cases of (3-hemolytic streptococcal infections, treatment should be continued for at least 10 days.

Interaction of Dalacin-IM/IV 300 Injection

Clindamycin improves the activity of other neuromuscular blocking specialists. In this manner, it ought to be utilized with caution in patients getting such operators. Hostility has been illustrated between clindamycin and erythromycin in vitro. Since of conceivable clinical noteworthiness, these two drugs ought to not be managed concurrently.

Contraindications

Clindamycin is contraindicated in patients already found to be touchy to clindamycin or any of the fixings of this medication.

Side Effects of Dalacin-IM/IV 300 Injection

The antagonistic impacts have been detailed with the utilize of clindamycin are- stomach torment, oesophagitis and oesophagial ulcer, sickness, heaving and loose bowels, pruritus, skin rashes, urticaria.

Pregnancy & Lactation

Pregnancy Category B. Clindamycin crosses the placenta in people. After different measurements, amniotic liquid concentrations were roughly 30% of maternal concentrations. Clindamycin ought to be utilized in pregnancy as it were in case clearly required. Clindamycin has been detailed to seem in breast milk. In this manner, it isn't prescribed for nursing moms in the event that not clearly required.

Precautions & Warnings

Clindamycin ought to be endorsed with caution in people with a history of gastrointestinal malady, especially colitis.

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.