Tenizide 20/12.5mg 7Pcs

Indications

To lower blood pressure, it's used to treat hypertension alone or in combination with other antihypertensive drugs. This combination medicine is recommended as a first treatment for patients who are likely to require numerous antihypertensive medications to meet their blood pressure objectives. Considerations such as baseline blood pressure, the desired goal, and the incremental likelihood of meeting goal with a combination versus monotherapy should all be considered when deciding whether to employ a combination as initial therapy. Depending on the patient's risk, blood pressure objectives may differ.s.

Pharmacology

Amlodipine is a dihydropyridine calcium channel blocker that prevents calcium ions from crossing the blood-brain barrier and entering vascular smooth muscle and cardiac muscle. Compared to cardiac muscle cells, amlodipine has a stronger effect on vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle.

Angiotensin II is a powerful vasoconstrictor, the principal vasoactive hormone of the Renin-angiotensin system, and an essential component in the pathogenesis of hypertension. It is generated from angiotensin I in a mechanism catalyzed by angiotensin-converting enzyme (ACE). It also causes the adrenal cortex to secrete more aldosterone.

By specifically blocking angiotensin II's binding to the AT1 receptor located in numerous tissues, Olmesartan Medoxomil reduces the vasoconstrictor and aldosterone-secreting effects of angiotensin II (e.g. vascular smooth muscle, adrenal gland). Olmesartan Medoxomil is a reversible, competitive AT1 receptor inhibitor, according to in vitro binding tests.

Dosage and Administration

Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil. This combination may also be given with increased amounts of Amlodipine, Olmesartan Medoxomil, or both, as needed.

Initial therapy: Initiate with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily. Due to decreased clearance of Amlodipine among elderly patients the recommended starting dose of Amlodipine is 2.5 mg in patients 75 years. The lowest dose of the combination is 5/20 mg; therefore, initial therapy with this combination drug is not recommended in patients >75 years old.

Interactions

NSAIDs such as selective COX-2 inhibitors may reduce the antihypertensive impact of angiotensin II receptor antagonists like Olmesartan Medoxomil. In patients receiving combination treatment or other medications that influence the RAS, blood pressure, renal function, and electrolytes should be continuously monitored.

Contraindications

In diabetic patients, this medication should not be taken together with Aliskiren.

Side effects

Peripheral edema, headache, flushing, and dizziness are the most prevalent adverse effects. It can also cause sprue-like enteropathy, which is a type of intestinal issue.

 Pregnancy and lactation

D is the pregnancy category. The combination of amlodipine and olmesartan medoxomil should not be used in the second or third trimester since it can cause fetal mortality. This combination should be stopped as soon as possible if pregnancy is detected. Olmesartan and Amlodipine are not known to be excreted in human milk. Because of the risk of harm to the nursing infant, a decision should be taken on whether to stop breastfeeding or stop taking the medicine, taking into account the drug's importance to the mother.

Precautions & Warnings

Amlodipine and Olmesartan Medoxomil combination should be used with caution because there is a risk for-

Hypotension in volume- or salt depleted patients.

Vasodilation in patients with severe aortic stenosis.

Increased frequency, duration or severity of angina or acute Ml in patients with severe obstructive coronary artery disease.

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.