Sevitan HTZ Tablet 7Pcs

Indications

The combination of Olmesartan Medoxomil and Hydrochlorothiazide is used to treat hypertension.

Pharmacology

Angiotensin-II shaped from angiotensin-I in a response catalyzed by angiotensin-converting protein (Expert), maybe a strong vasoconstrictor, the essential vasoactive hormone of the renin-angiotensin framework and a vital component within the pathophysiology of hypertension. It too fortifies aldosterone emission by the adrenal cortex. Olmesartan squares the vasoconstrictor and aldosterone-secreting impacts of angiotensin-II by specifically blocking the official of angiotensin-II to the AT 1 receptor found in numerous tissues (e.g. vascular smooth muscle, adrenal organ). In-vitro-binding ponders show that Olmesartan could be a reversible & competitive inhibitor of AT 1 receptor. Olmesartan does not repress Pro (kinase-I, the chemical that changes over angiotensin-I to angiotensin-II and corrupts bradykinin).

A thiazide diuretic is hydrochlorothiazide. Thiazides impact the electrolyte reabsorption systems in the kidney tubules, increasing sodium and chloride excretion in almost equal proportions. Hydrochlorothiazide's diuretic action reduces plasma volume, resulting in an increase in plasma renin activity, increases Aldosterone secretion and urinary Potassium loss, and lowers serum Potassium. Angiotensin II mediates the renin-aldosterone connection. As a result, taking an angiotensin-II receptor antagonist with these diuretics helps to reverse the potassium loss.

Dosage & Administration

Hypertension: The usual starting dose is 20/12.5 mg one tablet once daily. Dosing should be individualized. Depending on the blood pressure response, the dose may be titrated at intervals of 2-4 weeks to two tablets 40/25 once daily.

Interaction

In investigations in which Olmesartan Medoxomil was co-administered with hydrochlorothiazide, digoxin, or warfarin in healthy volunteers, no significant medication interactions were reported. Because Olmesartan Medoxomil is not metabolized by the cytochrome P450 system and has no effect on P450 enzymes, it is unlikely that it would interact with medications that inhibit, induce, or metabolize those enzymes.

Hydrochlorothiazide: The following medicines may interact with Thiazide diuretics if used at the same time:

Benzodiazepines, barbiturates, or narcotics: Orthostatic hypotension may be exacerbated.

Antidiabetic medicines (oral agents and Insulin): Antidiabetic drug dosage adjustments may be necessary.

Contraindications

Patients who are hypersensitive to either component of this medication should not use the combination of Olmesartan and Hydrochlorothiazide. This medication is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived pharmaceuticals due to the Hydrochlorothiazide component.

Side Effects

Nausea, headache, dizziness, hyperuricemia, upper respiratory tract infection, and urinary tract infection are all typical adverse effects. Chest pain, back pain, peripheral edema, abdominal pain, dyspepsia, gastroenteritis, and diarrhea are some of the other side effects.

Pregnancy & Lactation

The safety and effectiveness of the drug in nursing mothers and pregnant women has yet to be determined. During these circumstances, the medicine should be stopped.

Precautions & Warnings

To detect probable electrolyte imbalances such as hypokalemia, hyponatremia, and hypochloremic alkalosis, periodic testing of serum electrolytes should be performed at appropriate intervals.

Certain people on thiazide treatment may develop hyperuricemia.

Renal function is impaired.

Storage Conditions

Protect from light and moisture by storing in a cool, dry location. Keep out of children's reach.