Menaril 16mg (50pcs Box)

Indications of Menaril 16 Tablet

Menaril 16 prevents and treats Ménière's disease, an inner ear disorder. Symptoms include dizziness (vertigo), ringing in the ears (tinnitus), and hearing loss, which is most likely caused by fluid in the ear. This medication relieves symptoms by decreasing the amount of fluid in the body. To get the most benefit, Menaril 16 should be taken whole with water at the same time(s) every day. Your doctor will determine the appropriate dose to relieve your symptoms and how frequently you should take it. You may need to take this medication for several months, and you should take it for as long as your doctor prescribes.

Pharmacology of Menaril 16 Tablet

Betahistine works in a variety of ways. Meniere's disease is thought to be caused by a breakdown in the endolymphatic fluid equilibrium of the ear. Betahistine is primarily a histamine H1 receptor agonist. The stimulation of H1-receptors in the inner ear causes a vasodilatory effect in the blood vessels, resulting in increased permeability and a decrease in endolymphatic pressure; this action prevents labyrinth rupture, which can contribute to Ménière's disease hearing loss. Betahistine is also thought to alleviate vertigo symptoms by reducing asymmetry in the functioning of sensory vestibular organs and increasing vestibulocochlear blood flow.

Betahistine also acts as a histamine H3-receptor antagonist, increasing histamine turnover from postsynaptic histaminergic nerve receptors and, as a result, increasing H1-agonist activity. H3-receptor antagonism increases brainstem neurotransmitter levels, particularly serotonin, which inhibits vestibular nuclei activity, restoring normal balance and reducing vertigo symptoms.

Dosage & Administration of Menaril 16 Tablet

The usual starting dose is 8 mg to 16 mg three times per day, preferably with meals.
A maintenance dose is up to 48 mg daily is advised. Betahistine should not be used in children.

Interaction of Menaril 16 Tablet

There have been no reported instances of dangerous interactions. Although antagonism between Betahistine and antihistamines is possible, no such interchanges have been documented.

Contraindications

In pheochromocytoma, betahistine is not recommended.

Side Effects of Menaril 16 Tablet

Betahistine is generally well tolerated, and no significant side effects have been reported. Gastrointestinal problems, headaches, rashes, and pruritus have all been reported in rare cases.

Pregnancy 

In Pregnancy: Although there is no known teratogenic impact in animals, the safety of Betahistine in human pregnancy has not been fully proven. Before administering Betahistine during pregnancy, it's important to weigh the potential advantages carefully.

Lactation: Betahistine is excreted in similar amounts in the breast milk of nursing mothers as it is in the plasma. The neonate's toxicity at these amounts is unknown.

Precautions & Warnings

• Patients with bronchial asthma, low pressure, and peptic ulcer disease should be cautious.
• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.