Rimactazid 300/150mg Tablet 1 Strip

✔️ Side Effects of Rimactazid 300

1. General: Reddish discoloration of body fluids (e.g., urine, sweat, tears) caused by rifampicin, which can permanently stain contact lenses.
2. Hepatic effects: Commonly seen as elevated liver enzymes. Severe reactions like liver failure or acute hepatitis are less common but can be life-threatening.
3. Renal effects: Elevated BUN levels, hematuria, interstitial nephritis, or renal insufficiency.
4. Gastrointestinal effects: Nausea, abdominal pain, diarrhea, or pseudomembranous colitis.
5. Neurological effects: Fatigue, dizziness, headaches, confusion, or ataxia.
6. Hematological effects: Thrombocytopenia, eosinophilia, and leucopenia.
7. Skin and allergic reactions: Flushing, urticaria, rashes, or generalized hypersensitivity reactions (e.g., Lyell’s syndrome).

✔️ Dosage & Administration of Rimactazid 300

• For body weight <50 kg:
  • 3 tablets of 150/100 mg once daily or 1 tablet of 450/300 mg once daily.
• For body weight >50 kg:
  • 2 tablets of 300/150 mg once daily.
• For hepatic impairment: Maximum dose: 8 mg/kg daily.

Use under the guidance of a registered physician.

✔️ Drug Interactions

• Hormonal contraceptives: May reduce their effectiveness.
• Antacids: May decrease absorption.
• Rifampicin:
  • Can reduce plasma levels of antivirals (e.g., atazanavir, darunavir), antifungals (e.g., ketoconazole), anticonvulsants (e.g., phenytoin), oral anticoagulants, and other medications such as beta-blockers, corticosteroids, theophylline, and barbiturates.
  • May increase the risk of hepatotoxicity when used with halothane.
• Isoniazid:
  • May inhibit the metabolism of drugs such as anticonvulsants, benzodiazepines, ketoconazole, and warfarin.
  • Can enhance central nervous system effects when combined with medications like meperidine or disulfiram.

✔️ Contraindications

• Hypersensitivity to rifamycins, isoniazid, or any excipients in the formulation.
• History of drug-induced hepatitis or active liver disease.
• Conditions like peripheral neuritis.

✔️ Pregnancy & Lactation

• Pregnancy: Classified as Category C. While animal studies suggest potential risks to the fetus, benefits in managing tuberculosis may outweigh these risks in pregnant women.
• Lactation: Limited evidence suggests potential risks to the infant; consult a healthcare provider before use.

✔️ Precautions & Warnings

• Monitor use in:
  • Individuals consuming alcohol daily, as it increases the risk of isoniazid hepatitis.
  • Patients with chronic liver disease or severe renal impairment.
  • Individuals over 35 years of age or with predisposing conditions such as neuropathy.
  • Those taking other long-term medications or with a history of isoniazid discontinuation.
  • Postpartum women, HIV-positive patients, and those with a history of injection drug use.

✔️ Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.