Tridyl 2mg Tablet | 1 Strip

✔️ Side Effects

Common: dry mouth, blurred vision, dizziness, mild nausea, nervousness.
Rare: skin rashes, suppurative parotitis, paralytic ileus, psychiatric symptoms (hallucinations, paranoia), urinary retention, cognitive impairment, tachycardia, constipation, dilated pupils, increased intraocular pressure. Abrupt withdrawal can worsen Parkinsonism or cause neuroleptic malignant syndrome.

✔️ Dosage & Administration

Treatment should be individualized, starting with a low dose and gradually increasing, especially in patients over 60. Timing of meals should depend on patient response:

Idiopathic Parkinsonism: Start with 1 mg daily, increasing by 2 mg every 3–5 days until an optimal dose of 6–10 mg/day is reached (some may require 12–15 mg/day).

Drug-Induced Parkinsonism: Usually 5–15 mg/day, starting with 1 mg. Dosage is adjusted based on symptom control and may involve reducing the causative drug.

With Levodopa: Both drugs may require dose adjustment; 3–6 mg/day of Trihexyphenidyl in divided doses is often sufficient.

With Other Parasympathetic Inhibitors: Gradual substitution is recommended.
Daily doses are best divided into three meals, with high doses (>10 mg/day) split into four doses (three with meals, one at bedtime).
Not recommended for pediatric use.

✔️ Interaction

CNS depressants (alcohol, barbiturates, opiates, cannabinoids) may enhance sedative effects. MAO inhibitors and tricyclic antidepressants with anticholinergic properties may intensify side effects. Combined use with neuroleptics may raise the risk of tardive dyskinesia. Dosage adjustments are often needed when used with levodopa.

✔️ Contraindications:

Contraindicated in patients with hypersensitivity to Trihexyphenidyl or with narrow-angle glaucoma, as blindness from long-term use in such cases has been reported.

✔️ Pregnancy & Lactation

Use only if the benefits outweigh the potential risks. Unknown if excreted in breast milk; may reduce lactation. Exercise caution in nursing mothers.

✔️ Precautions & Warnings

• Assess intraocular pressure before and during treatment.
• Avoid in narrow-angle glaucoma; may trigger acute angle closure.
• Use cautiously in hot environments or with other anticholinergics due to the risk of anhidrosis and hyperthermia.
• Be aware of the potential for Neuroleptic Malignant Syndrome after dose reduction or abrupt discontinuation.

✔️ Storage:

Store below 30°C, in a dry place, protected from light.