Etocox 60mg 10pcs

Indications of Etocox 60

Acute pain and inflammation, Chronic musculo-skeletal pain, Osteoarthritis, Rheumatoid arthritis, Acute gouty arthritis, Primary dysmenorrhoea, Ankylosing spondylitis.

Pharmacology

Etoricoxib is an effective and orally active specific cyclooxygenase 2 (COX2) inhibitor, within the clinical dose range and significantly higher than the clinical dose range. Two isoforms of cyclooxygenase have been identified: cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2). COX1 is responsible for normal prostaglandin-mediated physiological functions, such as gastric cell protection and platelet aggregation. The inhibition of COX1 by non-selective NSAID is related to the inhibition of gastric injury and platelet aggregation. COX2 has been shown to be mainly responsible for the synthesis of prostaglandin mediators for pain, inflammation and fever. Selective inhibition of COX2 by etoricoxib (within the clinical dose range) reduces these clinical signs and symptoms, while reducing the possibility of GI toxicity and the effect on platelet aggregation. Etoricoxib produces dose-dependent COX2 inhibition, but does not inhibit COX1, up to 150 mg per day. Etoricoxib does not inhibit gastric prostaglandin synthesis.

Dosage & Administration

Adult and adolescent (over 16 years) :

Arthritis

Osteoarthritis: 60 mg once daily,

Rheumatoid arthritis : 90 mg once daily,

Acute gouty arthritis : 120 mg once daily.

Analgesia

Acute pain associated with dental surgery: 120 mg once daily,

Primary dysmenorrhoea, Chronic musculo-skeletal pain, including chronic low back pain : 60 mg once daily.

Interaction of Etocox 60

Warfarin, ACE inhibitor, Rifampicin, Lithium, birth control pills, Methotrexate, Digoxin.

Contraindications

Patients with known hypersensitivity to Etoricoxib or to any of the excipients of this medicinal product. Active peptic ulceration or gastro-intestinal (GI) bleeding, severe hepatic dysfunction. Children and adolescents under 16 years of age.Patients with inflammatory bowel disease and severe congestive heart failure.

Side Effects of Etocox 60

Common side effects are dizziness, headache, gastro-intestinal disorders (e.g. abdominal pain, flatulence, heartburn), diarrhoea, dyspepsia, nausea, asthenia, fatigue, flu-like symptoms. Rare side effects are oedema, weight gain, anxiety, blurred vision, hypertension, epistaxis, dyspnoea, constipation, vomiting, muscle cramps, chest pain.

Pregnancy & Lactation

Not recommended.

Precautions & Warnings

Decreased kidney function and liver function, dehydration, hypertension, history of heart failure, perforation and people over 65 years of age.

Storage Conditions

Store at a temperature of below 30°C, protect from light & moisture. Keep out of reach of children.