Sintel 400 | 1 Strip

✔️ Mode of Action

Albendazole works by inhibiting glucose uptake in parasites, depleting their energy stores. This leads to impaired survival and eventual death of the parasite.

✔️ Dosage Guidance

Take as prescribed by the physician.

Overdose symptoms: Nausea, vomiting, abdominal cramps, diarrhea, dizziness, seizures, fatigue, and sleep disturbance. Immediate medical care is required.

Missed dose: Take as soon as remembered, but skip if it’s almost time for the next dose. Do not double the dose.

✔️ Side Effects

Common:

• Headache, dizziness
• Nausea, vomiting, abdominal pain, diarrhea
• Fever
• Elevated liver enzymes
• Hair thinning or hair loss (reversible)

Uncommon/Rare:

• Rash, itching, skin reactions (blisters, redness)
• Decreased white blood cells (leukopenia)
• Liver dysfunction or hepatitis
• Bone marrow suppression (rare: pancytopenia, aplastic anemia, agranulocytosis)

✔️ Drug Interactions

Anti-seizure drugs: Carbamazepine, Phenytoin, Phenobarbital (reduce Albendazole effectiveness).

Cimetidine (antacid): May increase drug levels.

Praziquantel: May enhance Albendazole action.

Dexamethasone: Increases Albendazole concentration.

Ritonavir: May alter metabolism.

With Food:

Must be taken with food (preferably fatty meals) to improve absorption.

Avoid grapefruit juice, as it alters drug levels.

✔️ Contraindications

Known hypersensitivity to Albendazole or any excipient of the formulation.

Should not be used during pregnancy unless clearly necessary.

✔️ Precautions & Warnings

Pregnancy: Avoid use (Category C). May harm the fetus.

Breastfeeding: Insufficient data; best avoided.

Driving/Operating Machinery: Avoid if dizziness or tiredness occurs.

Alcohol: Should be limited, as both alcohol and Albendazole may increase the risk of liver damage.

Medical Supervision: Regular monitoring of blood counts and liver function tests is recommended during long-term therapy.

Caution in patients with:

• Seizures or neurocysticercosis
• Pre-existing liver disease
• Bone marrow suppression