Sefur 125 Tablet | 1 Strip

✔️ Side Effects

Generally mild and short-lived, including rash and gastrointestinal upset. Prolonged use may lead to overgrowth of non-susceptible organisms (e.g., Candida).

✔️ Dosage & Administration

Oral (Tablets/Suspension)

Adults & adolescents (13+ years)

Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days

Acute exacerbations of chronic bronchitis: 250–500 mg twice daily for 10 days

Secondary bacterial infections of acute bronchitis: 250–500 mg twice daily for 5–10 days

Uncomplicated skin/skin-structure infections: 250–500 mg twice daily for 10 days

Uncomplicated UTI: 250 mg twice daily for 7–10 days

Uncomplicated Gonorrhoea: Single dose of 1000 mg

Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

MDR Typhoid Fever: 500 mg twice daily for 10–14 days

Early Lyme disease: 500 mg twice daily for 20 days

Children (3 months–12 years)

Pharyngitis/Tonsillitis: 20 mg/kg/day in 2 doses for 5–10 days

Acute otitis media: 30 mg/kg/day in 2 doses for 10 days

Acute bacterial maxillary sinusitis: 30 mg/kg/day in 2 doses for 10 days

Impetigo: 30 mg/kg/day in 2 doses for 10 days

Parenteral (Injection)

Adults: 750 mg IM/IV every 8 hours; severe infections up to 1.5 g every 8 hours. May increase to 4 doses/day if needed (3–6 g/day).

Children (over 3 months): 30–100 mg/kg/day in 3–4 doses (60 mg/kg/day for most infections).

Neonates: 30–100 mg/kg/day in 2–3 doses.

Special cases:

Surgical prophylaxis: 1.5 g IV at anesthesia induction, followed by up to 3 doses of 750 mg every 8 hours for high-risk procedures.

Pneumonia: 1.5 g IV twice daily for 2–3 days, then switch to 500 mg orally twice daily for 7–10 days.

Acute bronchitis exacerbation: 750 mg twice daily for 2–3 days, then 500 mg orally twice daily for 5–10 days.

Gonorrhoea: 1.5 g as a single dose (two 750 mg injections at separate sites).

Meningitis: Adults 3 g IV every 8 hours; children 200–240 mg/kg/day IV in 3–4 doses (reduce after improvement); neonates 100 mg/kg/day IV (reduce to 50 mg/kg/day when indicated).

Bone/joint infections: Adults 1.5 g IV every 6 hours; children 150 mg/kg/day divided into doses every 8 hours (max adult dose).

✔️ Interactions

No significant hazardous drug interactions reported.

✔️ Contraindications

Do not use in patients allergic to cephalosporins.

✔️ Pregnancy & Lactation

FDA Pregnancy Category B. Use only if needed. Excreted in breast milk—use with caution in nursing women.

✔️ Precautions & Warnings

Use cautiously in patients taking strong diuretics or with a history of colitis. Cross-reactivity may occur in penicillin-allergic patients.

✔️ Storage

Keep in a cool, dry place (below 30°C), protected from light and moisture. Keep out of reach of children.