Emixef 400 Capsule 1 Strip

✔️ Dosage & Administration

Food does not significantly influence absorption.
The usual treatment duration is 7 days, which may be extended up to 14 days if clinically required.

Adults and Children ≥10 years

200–400 mg daily, administered as a single dose or in two divided doses, depending on infection severity

Elderly

Same dosage as adults

Renal function should be assessed, with dose adjustment in severe renal impairment

Children

8 mg/kg/day, given once daily or in two divided doses

Suggested suspension dosing:

6 months–1 year: 3.75 ml daily

1–4 years: 5 ml daily

5–10 years: 10 ml daily

Typhoid fever (children):

5 mg/kg body weight twice daily for 10–14 days

Children weighing >50 kg or aged ≥10 years should receive adult dosing.

⚠️ Safety and efficacy have not been established in children below 6 months of age.

Dosage in Renal Impairment

Creatinine clearance ≥20 ml/min: Normal dosing may be used

Creatinine clearance <20 ml/min: Maximum dose should not exceed 200 mg once daily

Patients on hemodialysis or peritoneal dialysis should follow the same dosing recommendations as those with creatinine clearance <20 ml/min

✔️ Side Effects

Emixef is generally well tolerated, with most adverse reactions being mild and self-limiting.

Gastrointestinal

Diarrhea (more common with higher doses)

Nausea

Abdominal pain

Dyspepsia

Vomiting

Flatulence

Rarely, pseudomembranous colitis

Central Nervous System

Headache

Dizziness

Hypersensitivity Reactions

Rash

Pruritus

Urticaria

Drug fever

Arthralgia
These typically resolve upon discontinuation.

Hematologic & Laboratory Changes

Thrombocytopenia

Leukopenia

Eosinophilia

Mild, transient elevations in liver and renal function tests

Miscellaneous

Genital pruritus

Vaginitis

✔️ Drug Interactions

As with other cephalosporins, cefixime may cause prolongation of prothrombin time in some patients. Caution is advised when administered concurrently with anticoagulant therapy.

✔️ Contraindications

Known hypersensitivity to cephalosporin antibiotics

✔️ Pregnancy & Lactation

Adequate and well-controlled studies in pregnant women are lacking. Cefixime should be used during pregnancy only if clearly necessary. It is not known whether cefixime is excreted in human breast milk; therefore, caution is advised when administered to nursing mothers.

✔️ Precautions & Warnings

Use with caution in patients with a history of drug hypersensitivity

Partial cross-reactivity may occur in penicillin-sensitive patients

Discontinue immediately if allergic reactions occur

Use cautiously in patients with severe renal impairment

Broad-spectrum antibiotic use may lead to Clostridium difficile–associated diarrhea

✔️ Storage:

Store below 30°C, protected from light and moisture.
Keep out of reach of children.