Atova 40mg 10pcs

✔️ Dosage & Administration

Adults (Primary hypercholesterolemia / Mixed dyslipidemia): Start with 10 mg once daily. Dose may be adjusted at ≥4-week intervals, up to a maximum of 80 mg once daily.

Adults (Familial hypercholesterolemia): 10–40 mg daily; may be increased to 80 mg if needed.

Children (10–18 years): Start at 10 mg once daily; maximum 20 mg/day (higher doses not studied).

Prevention of cardiovascular events: Usual starting dose 10 mg once daily; titrate as per response.

Elderly: Higher plasma concentrations; enhanced LDL-C reduction observed.

Renal impairment: No dose adjustment required. Hemodialysis has minimal effect due to protein binding.

Hepatic impairment: Markedly increased plasma concentrations—use with caution.

Gender: No significant differences in efficacy between men and women.

👉 Atova can be taken with or without food, at any time of the day. Patients should remain on a cholesterol-lowering diet throughout therapy. Lipid levels should be checked 2–4 weeks after initiation or dose adjustment.

✔️ Side Effects

Generally well tolerated. Common reactions include:

Gastrointestinal: constipation, flatulence, indigestion, abdominal pain.

Other: headache, rash, infection, back pain, fatigue, joint or muscle pain.

✔️ Interaction

• Increased risk of myopathy: with cyclosporine, fibrates, niacin, erythromycin, azole antifungals.
• Antacids: Lower atorvastatin levels by ~35%, but LDL-C reduction is unaffected.
• Colestipol: Lowers atorvastatin levels by ~25%, but lipid-lowering effect is enhanced when combined.
• Digoxin: Plasma concentration ↑ ~20%. Monitor levels.
• Erythromycin: Atorvastatin exposure ↑ ~40% due to CYP3A4 inhibition.
• Oral contraceptives: Norethindrone and ethinyl estradiol exposure ↑ by ~30% and 20%.
• Warfarin: No significant effect on anticoagulant activity.

✔️ Contraindications

Hypersensitivity to atorvastatin or formulation components.

Active liver disease or unexplained persistent transaminase elevation.

Pregnancy and breastfeeding.

Prior serious adverse reaction to statins.

✔️ Pregnancy & Lactation

Pregnancy: Contraindicated. Atorvastatin may interfere with fetal cholesterol synthesis, with possible teratogenic effects.

Lactation: Contraindicated. Excreted in rat milk; potential for adverse effects in infants.

✔️ Precautions & Warnings

Monitor liver function before treatment and periodically during therapy.

Discontinue if significant CPK elevation, myopathy, or liver dysfunction occurs.

Use cautiously in patients with history of liver disease or heavy alcohol use.

✔️ Storage:

Store in a cool, dry place, protected from heat and light. Keep out of reach of children.