Torsem 5 Tablet 1 Strip

✔️ Torsem 5 Generally well-tolerated. Possible side effects include:

• Dizziness, fatigue
• Dry mouth
• Nausea, vomiting, diarrhea, constipation
• Orthostatic hypotension
• Skin rash
• Muscle cramps

✔️ Dosage & Administration of Torsem 5

Edema due to Congestive Heart Failure:
Start with 10–20 mg orally once daily. Increase the dose by doubling gradually if needed. Doses above 200 mg have not been studied.

Chronic Renal Failure:
Begin with 20 mg once daily, increasing gradually if necessary. The maximum studied dose is 200 mg.

Hepatic Cirrhosis:
Initial dose: 5–10 mg once daily, combined with a potassium-sparing agent or aldosterone antagonist. Adjust gradually as needed. Doses above 40 mg have not been adequately evaluated.

Hypertension:
Start with 2.5–5 mg orally once daily. If blood pressure is not controlled within 4–6 weeks, increase to 10 mg once daily. If inadequate, consider adding another antihypertensive.

✔️ Overdose Management

Symptoms may include dehydration, hypotension, electrolyte imbalance, especially hypokalemia. Treatment involves supportive care with fluid and electrolyte replacement.

✔️ Drug Interactions

• Increased risk of hypokalemia when used with amphotericin B, corticosteroids, or other potassium-depleting agents.
• May enhance digoxin and lithium toxicity.
• May increase the risk of ototoxicity/nephrotoxicity when combined with aminoglycosides or similar drugs.
• NSAIDs may reduce diuretic efficacy.
• Antihypertensives may enhance blood pressure-lowering effects.
• High-dose salicylates may increase toxicity.

✔️ Contraindications

• Known hypersensitivity to torasemide or sulfonylureas.
• Anuria (no urine output).

✔️ Use in Pregnancy & Lactation

Pregnancy: Use only if needed, as adequate human studies are lacking.

Breastfeeding: Unknown if excreted in breast milk; caution is advised.

✔️ Precautions

Use with care in patients with diabetes, hypotension, gout, or liver disease.

Monitor fluid and electrolyte balance closely, especially in elderly or debilitated patients.

✔️ Storage

Keep at room temperature (below 30°C) in a cool, dry place, protected from light and moisture. Keep out of reach of children.