Xpa 500mg 10pcs

Indications

Fever, common cold, and influenza, headache, toothache, earache, body ache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post-vaccination pain in children are among the conditions for which paracetamol is prescribed. It's also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.

Pharmacology

Paracetamol has pain-relieving and antipyretic properties with powerless anti-inflammatory action. Paracetamol (Acetaminophen) is thought to act fundamentally within the CNS, expanding the torment limit by hindering both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 proteins included in prostaglandin (PG) synthesis. Paracetamol may be a para aminophenol subordinate and has pain-relieving and antipyretic properties with frail anti-inflammatory movement. Paracetamol is one of the foremost broadly utilized, most secure, and quick-acting pain relieving. It is well endured and free from different side impacts of aspirin.

Dosage & Administration

Tablet:

Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.

Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long-term treatment, it is wise not to exceed the dose beyond 2.6 gm/day.

Extended Release Tablet:

Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). The tablet must not be crushed.

Syrup/Suspension:

Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.

3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.

1-5 years: 1 -2 teaspoonfuls 3 to 4 times daily.

6-12 years: 2-A teaspoonfuls 3 to 4 times daily.

Adults: 4-8 teaspoonful 3 to 4 times daily.

Suppository:

Children 3-12 months: 60-120 mg,4 times daily.

Children 1-5 years: 125-250 mg 4 times daily.

Children 6-12 years: 250-500 mg 4 times daily.

Adults & children over 12 years: 0.5-1 gm 4 times daily.

Pediatric Drop:

Children Upto 3 months: 0.5 ml (40 mg)

4 to 11 months: 1.0 ml (80 mg)

7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 doses daily for a maximum of 5 days.

Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast-acting and safe analgesic with marked antipyretic properties. It is especially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.

Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interaction

Patients who have taken barbiturates, tricyclic antidepressants, and liquor may appear lessened capacity to metabolize expansive dosages of Paracetamol. Liquor can increment the hepatotoxicity of Paracetamol overdosage. Persistent ingestion of anticonvulsants or verbal steroid contraceptives initiates liver chemicals and may anticipate the fulfillment of helpful Paracetamol levels by expanding the first-pass digestion system or clearance.

Contraindications

It is not recommended if you have a known hypersensitivity to paracetamol.

Side Effects

Although hematological responses such as thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been observed, paracetamol's side effects are usually minor. Pancreatitis, rashes, and other allergic responses can happen at any time.

Pregnancy & Lactation

According to the USFDA, pregnancy category B. This medication should only be used during pregnancy if absolutely necessary.

Precautions & Warnings

Patients with compromised kidney or liver function should use paracetamol with caution. Patients taking other medicines that damage the liver should use caution when using paracetamol.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.