Prucon 2 | 1 Strip

✔️ Dosage & Administration | Prucon 2

Adults: 2 mg once daily, with or without food, at any time of day. Doses above 2 mg do not enhance efficacy.

Elderly: Start with 1 mg once daily; may increase to 2 mg if required.

Children & Adolescents (<18 years): Not recommended.

✔️ Interaction | Prucon 2

Minimal interaction potential; prucalopride does not significantly affect CYP-mediated drug metabolism.

May be a weak substrate of P-glycoprotein (P-gp) but is not an inhibitor at therapeutic doses.

Ketoconazole (200 mg b.i.d.) increases systemic exposure by ~40% (not clinically relevant). Similar effects may occur with strong P-gp inhibitors (e.g., verapamil, cyclosporine A, quinidine).

No significant interactions reported with warfarin, digoxin, alcohol, paroxetine, or oral contraceptives.

✔️ Side Effects | Prucon 2

Headache (~18%)

Gastrointestinal symptoms: abdominal pain, nausea, diarrhea

These effects are usually mild-to-moderate, occur early in therapy, and often resolve within a few days.

Rare: other mild adverse reactions.

✔️ Use in Pregnancy & Lactation

Pregnancy: Not recommended. Effective contraception should be used during treatment. Animal studies show no direct harmful effects, but human data are lacking.

Breastfeeding: Avoid use due to insufficient safety data.

✔️ Precautions & Warnings

Renal excretion is the main elimination pathway.

Severe renal impairment (GFR <30 ml/min/1.73 m²): 1 mg once daily.

Hepatic impairment:

Severe (Child-Pugh C): Start with 1 mg once daily, may increase to 2 mg if tolerated.

Mild-to-moderate: No dose adjustment needed.

Severe diarrhea may reduce oral contraceptive effectiveness—advise additional contraception.

Contains lactose → contraindicated in patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

✔️ Contraindications:

Known hypersensitivity to prucalopride or excipients.

Severe renal impairment requiring dialysis.

✔️ Storage:

Store below 30°C, in original packaging with desiccant.

Keep away from moisture and out of children’s reach.