Tilkotil 20 Tablet | 1 Strip

✔️ Side Effects

Generally well tolerated at prescribed doses, but possible side effects include mild, temporary gastrointestinal discomfort, abdominal pain, indigestion, heartburn, nausea, dizziness, headache, skin rashes, itching, swelling, elevated BUN or creatinine, and palpitations. Rarely, serious effects like GI perforation, asthma, angioedema, or hypertension may occur.

✔️

The typical adult dose for most indications (except primary dysmenorrhea, post-operative pain, and acute gout) is 20 mg once daily, taken at the same time each day. In rheumatoid arthritis, nighttime dosing may help ease morning stiffness.

Primary dysmenorrhea: 20–40 mg once daily

Post-operative pain: 40 mg once daily for up to 5 days

Acute gout: 40 mg once daily for 2 days, then 20 mg once daily for the next 5 days
Tenoxicam is not recommended for patients under 16 years of age.

✔️ Drug Interactions

Salicylates can increase the clearance and distribution of tenoxicam by displacing it from protein-binding sites, so concurrent use with salicylates or other NSAIDs is discouraged due to higher side-effect risks. When used with methotrexate, it may reduce renal tubular secretion of methotrexate. It should not be combined with potassium-sparing diuretics and may reduce the antihypertensive effects of beta-blockers and ACE inhibitors. It may also enhance the effect of sulfonylurea antidiabetic drugs.

✔️ Contraindications

Tenoxicam should not be used in patients with active peptic ulcers, gastrointestinal inflammation, known hypersensitivity to the drug, or a history of asthma, urticaria, rhinitis, or other allergic reactions to aspirin or other NSAIDs, as severe allergic reactions may occur. It is contraindicated in elderly patients at risk of renal failure, those with a high bleeding risk before surgery, or those with significant liver disease.

✔️ Pregnancy & Lactation

Safety during pregnancy has not been established, so it should only be used if the benefits outweigh the risks. Due to a lack of safety data during breastfeeding, it is not recommended while nursing.

✔️ Precautions & Warnings

Use cautiously in patients with gastrointestinal disorders. Discontinue immediately if ulcers or bleeding occur. Monitor patients at risk of renal impairment, including those with diabetes, hepatic cirrhosis, or heart failure. Closely watch patients with bleeding disorders or on medications affecting clotting. Consider discontinuing in women with fertility issues or undergoing infertility evaluation.

✔️ Storage:

Store in a cool, dry place, away from light and out of reach of children.